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tool to diagnose

Infrared spectroscopy coupled to cloud-based data management as a tool to diagnose malaria: a pilot study in a malaria-endemic country

October 22, 2019 - 16:27 -- Open Access
Author(s): 
Philip Heraud, Patutong Chatchawal, Molin Wongwattanakul, Patcharaporn Tippayawat, Christian Doerig, Patcharee Jearanaikoon, David Perez-Guaita and Bayden R. Wood
Reference: 
Malaria Journal 2019 18:348, 16 October 2019

Widespread elimination of malaria requires an ultra-sensitive detection method that can detect low parasitaemia levels seen in asymptomatic carriers who act as reservoirs for further transmission of the disease, but is inexpensive and easy to deploy in the field in low income settings. It was hypothesized that a new method of malaria detection based on infrared spectroscopy, shown in the laboratory to have similar sensitivity to PCR based detection, could prove effective in detecting malaria in a field setting using cheap portable units with data management systems allowing them to be used by users inexpert in spectroscopy. This study was designed to determine whether the methodology developed in the laboratory could be translated to the field to diagnose the presence of Plasmodium in the blood of patients presenting at hospital with symptoms of malaria, as a precursor to trials testing the sensitivity of to detect asymptomatic carriers.

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