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within-host replication

Host circadian clocks do not set the schedule for the within-host replication of malaria parasites

August 13, 2020 - 11:36 -- Open Access
Author(s): 
O'Donnell AJ, Prior KF, Reece SE
Reference: 
Proc Biol Sci. 2020 Aug 12;287(1932):20200347

Circadian clocks coordinate organisms' activities with daily cycles in their environment. Parasites are subject to daily rhythms in the within-host environment, resulting from clock-control of host activities, including immune responses. Parasites also exhibit rhythms in their activities: the timing of within-host replication by malaria parasites is coordinated to host feeding rhythms. Precisely which host feeding-related rhythm(s) parasites align with and how this is achieved are unknown.

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