The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10625 malaria professionals are enjoying the free benefits of MalariaWorld today

microRNAs

The characterization of extracellular vesicles-derived microRNAs in Thai malaria patients

August 11, 2020 - 13:52 -- Open Access
Author(s): 
Nutpakal Ketprasit, Iris Simone Cheng, Fiona Deutsch, Nham Tran, Mallika Imwong, Valery Combes and Duangdao Palasuwan
Reference: 
Malaria Journal 2020 19:285, 10 August 2020

Extracellular vesicles (EVs) have been broadly studied in malaria for nearly a decade. These vesicles carry various functional biomolecules including RNA families such as microRNAs (miRNA). These EVs-derived microRNAs have numerous roles in host-parasite interactions and are considered promising biomarkers for disease severity. However, this field lacks clinical studies of malaria-infected samples. In this study, EV specific miRNAs were isolated from the plasma of patients from Thailand infected with Plasmodium vivax and Plasmodium falciparum. In addition, it is postulated that these miRNAs were differentially expressed in these groups of patients and had a role in disease onset through the regulation of specific target genes.

Subscribe to RSS - microRNAs