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chabaudi

Caspase-8 mediates inflammation and disease in rodent malaria

September 16, 2020 - 13:03 -- Open Access
Author(s): 
Pereira LMN, Assis PA, Gazzinelli RT, et al.
Reference: 
Nat Commun. 2020 Sep 14;11(1):4596

Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM).

NOT Open Access | Plasmodium chabaudi-infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract

August 5, 2020 - 16:13 -- NOT Open Access
Author(s): 
Al-Quraishy S, Murshed M, Delic D, Al-Shaebi EM, Qasem MAA, Mares MM, Dkhil MA
Reference: 
Lett Appl Microbiol. 2020 Aug 4

Malaria is a worldwide serious-threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti-inflammatory activity of nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the infection with Plasmodium chabaudi caused in mice spleen.

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