Caspase-8 mediates inflammation and disease in rodent malaria
Reference:
Nat Commun. 2020 Sep 14;11(1):4596
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM).
