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blood stage infection

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

August 24, 2020 - 13:03 -- Open Access
Schäfer C, Roobsoong W, Kappe SHI, et al.
iScience. 2020 Aug 21;23(8):101381

The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block P. vivax parasite transition from liver stage infection to blood stage infection. Human liver-chimeric FRGN huHep mice infected with P. vivax sporozoites were infused with human reticulocytes, allowing transition of exo-erythrocytic merozoites to reticulocyte infection and development into all erythrocytic forms, including gametocytes, in vivo.

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

August 9, 2020 - 16:31 -- Open Access
Zhao Y, Hosking C, Cunningham D, Langhorne J, Lin JW
Sci Data. 2020 Aug 4;7(1):253

Malaria is a devastating infectious disease and the immune response is complex and dynamic during a course of a malarial infection. Rodent malaria models allow detailed time-series studies of the host response in multiple organs. Here, we describe two comprehensive datasets containing host transcriptomic data from both the blood and spleen throughout an acute blood stage infection of virulent or avirulent Plasmodium chabaudi infection in C57BL/6 mice.

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