Malaria is a deadly disease. It is mostly treated using 4-aminoquinoline derivatives such as chloroquine etc. because it is well tolerated, display low toxicity and after administration, it is rapidly absorbed. The combination of 4-aminoquinoline with other classes of antimalarial drugs has been reported to be an effective approach for the treatment of malaria. Furthermore, some patents reported hybrids 4-aminoquinolines containing ferrocene moiety with potent antimalarial activity.