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4-aminoquinoline-ferrocene hybrids

NOT Open Access | 4-Aminoquinoline-ferrocene Hybrids as Potential Antimalarials

August 5, 2020 - 16:27 -- NOT Open Access
Nqoro X, Aderibigbe BA
Recent Pat Antiinfect Drug Discov. 2020 Aug 4

Malaria is a deadly disease. It is mostly treated using 4-aminoquinoline derivatives such as chloroquine etc. because it is well tolerated, display low toxicity and after administration, it is rapidly absorbed. The combination of 4-aminoquinoline with other classes of antimalarial drugs has been reported to be an effective approach for the treatment of malaria. Furthermore, some patents reported hybrids 4-aminoquinolines containing ferrocene moiety with potent antimalarial activity.

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