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cynomolgi

NOT Open Access | A chimeric Plasmodium vivax Merozoite Surface Protein Antibody Recognises and Blocks Erythrocytic P. cynomolgi Berok Merozoites In Vitro

November 18, 2020 - 12:13 -- NOT Open Access
Author(s): 
Shen FH, Ong JJY, Sun YF, Lei Y, Chu RL, Kassegne K, Fu HT, Jin C, Han ET, Russell B, Han JH, Cheng Y
Reference: 
Infect Immun. 2020 Nov 16:IAI.00645-20

Research on erythrocytic Plasmodium vivax merozoite antigens is critical for identifying potential vaccine candidates in reducing vivax disease. However, many P. vivax studies are constrained by its inability to undergo long-term culture in vitro Conserved across all Plasmodium spp, merozoite surface proteins are essential for invasion into erythrocytes and highly expressed on erythrocytic merozoites, thus making it an ideal vaccine candidate.

Chloroquine Potentiates Primaquine Activity Against Active and Latent Hepatic Plasmodia Ex vivo: Potentials and Pitfalls

October 21, 2020 - 09:26 -- Open Access
Author(s): 
Dembélé L, Franetich JF, Snounou G, et al.
Reference: 
Antimicrob Agents Chemother. 2020 Oct 19:AAC.01416-20

8-aminoquinoline compounds have long been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of Plasmodium cynomolgi, Plasmodium yoelii, Plasmodium berghei, and Plasmodium falciparum within several ex vivo systems: primary hepatocytes of Macaca fascicularis; primary human hepatocytes; and stably transformed human hepatocarcinoma cell line HepG2.

Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo

August 4, 2020 - 15:27 -- Open Access
Author(s): 
Raja TN, Hu TH, Kadir KA, Mohamad DSA, Rosli N, Wong LL, Hii KC, Simon Divis PC, Singh B
Reference: 
Emerg Infect Dis. 2020 Aug; 26(8):1801-1809

To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845 (80.6%) patients had either P. knowlesi monoinfection (n = 815) or co-infection with other Plasmodium species (n = 30).

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