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In vivo efficacy of anti-malarial drugs against clinical Plasmodium vivax malaria in Ethiopia: a systematic review and meta-analysis

January 12, 2022 - 23:09 -- Open Access
Tsige Ketema, Ketema Bacha, Kefelegn Getahun and Quique Bassat
Malaria Journal 2021 20:483, 24 December 2021

Ethiopia is one of the few countries in Africa where Plasmodium vivax commonly co-exists with Plasmodium falciparum, and which accounts for ~ 40% of the total number of malaria infections in the country. Regardless of the growing evidence over many decades of decreasing sensitivity of this parasite to different anti-malarial drugs, there has been no comprehensive attempt made to systematically review and meta-analyse the efficacy of different anti-malarial drugs against P. vivax in the country. However, outlining the efficacy of available anti-malarial drugs against this parasite is essential to guide recommendations for the optimal therapeutic strategy to use in clinical practice. The aim of this study was to synthesize evidence on the efficacy of anti-malarial drugs against clinical P. vivax malaria in Ethiopia.

Prevalence and outcomes of malaria as co-infection among patients with human African trypanosomiasis: a systematic review and meta-analysis

December 14, 2021 - 21:06 -- Open Access
Kotepui KU, Masangkay FR, De Jesus Milanez G, Kotepui M
Sci Rep. 2021 Dec 10;11(1):23777

Human African trypanosomiasis (HAT) is endemic in Africa; hence, the possibility of co-infection with malaria among patients with HAT exists. The present study investigated co-infection with malaria among patients with HAT to provide current evidence and characteristics to support further studies. Potentially relevant studies that reported Plasmodium spp. infection in patients with HAT was searched in PubMed, Web of Science, and Scopus. The risk of bias among the included studies was assessed using the checklist for analytical cross-sectional studies developed by the Joanna Briggs Institute.

Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis

November 3, 2021 - 20:22 -- Open Access
Ray STJ, Fuller C, Boubour A, Bonnett LJ, Lalloo DG, Seydel KB, Griffiths MJ
Syst Rev. 2021 Oct 29;10(1):282

Non-traumatic coma is a common acute childhood presentation to healthcare facilities in Africa and is associated with high morbidity and mortality. Historically, the majority of cases were attributed to cerebral malaria (CM). With the recent drastic reduction in malaria incidence, non-malarial coma is becoming a larger proportion of cases and determining the aetiology is diagnostically challenging, particularly in resource-limited settings. The purpose of this study will be to evaluate the aetiology and prognosis of non-traumatic coma in African children.

Comorbidity of Geo-Helminthes among Malaria Outpatients of the Health Facilities in Ethiopia: Systematic Review and Meta-Analysis

October 30, 2021 - 12:56 -- Open Access
Boltena MT, El-Khatib Z, Sahlemichael Kebede A, Asamoah BO, Tadesse Boltena A, Yeshambaw M, Biru M
Int J Environ Res Public Health. 2021 Jan 20;18(3):862

Coinfection of malaria and intestinal helminths affects one third of the global population, largely among communities with severe poverty. The spread of these parasitic infections overlays in several epidemiological locations and the host shows different outcomes. This systematic review and meta-analysis determine the pooled prevalence of malaria and intestinal helminthiases coinfections among malaria suspected patients in Ethiopia.

NOT Open Access | The efficacy and safety of intermittent preventive treatment with sulphadoxine-pyrimethamine vs artemisinin-based drugs for malaria: a systematic review and meta-analysis

October 23, 2021 - 20:08 -- NOT Open Access
Chu X, Yan P, Zhang N, Chen N, Liu Y, Feng L, Li M, Zhang Z, Wang Q, Wang S, Yang K
Trans R Soc Trop Med Hyg. 2021 Oct 14:trab152

Malaria is one of the most serious global problems. The objective of this study is to assess whether intermittent preventive treatment (IPT) using artemisinin-based combination therapies (ACTs) was a promising alternative to IPT with sulphadoxine-pyrimethamine (IPT-SP).

Assessing field performance of ultrasensitive rapid diagnostic tests for malaria: a systematic review and meta-analysis

June 9, 2021 - 07:34 -- Open Access
Celestin Danwang, Fati Kirakoya-Samadoulougou and Sekou Samadoulougou
Malaria Journal 2021 20:245, 3 June 2021

To overcome the limitations of conventional malaria rapid diagnostic tests (cRDTs) in diagnosing malaria in patients with low parasitaemia, ultrasensitive malaria rapid diagnostic tests (uRDTs) have recently been developed, with promising results under laboratory conditions. The current study is the first meta-analysis comparing the overall sensitivity, and specificity of newly developed ultrasensitive Plasmodium falciparum malaria RDT (Alere™ Ultra-sensitive Malaria Ag P. falciparum RDT) with the cRDT conducted in the same field conditions.

Not Open Access | Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic review and meta-analysis

June 1, 2021 - 12:41 -- NOT Open Access
Edington FLB, Gadellha SR, Santiago MB
Eur J Intern Med. 2021 Jun;88:63-72

To estimate the incidence rate ratio (IRR) of adverse events (AE) in chloroquine or hydroxychloroquine users.

The high risk of malarial recurrence in patients with Plasmodium-mixed infection after treatment with antimalarial drugs: a systematic review and meta-analysis

May 26, 2021 - 14:40 -- Open Access
Mahittikorn A, Masangkay FR, Kotepui KU, Milanez GJ, Kotepui M
Parasit Vectors. 2021 May 25;14(1):280

Malaria mixed infections are often unrecognized by microscopists in the hospitals, and a delay or failure to treat Plasmodium-mixed infection may lead to aggravated morbidity and increased mortality. The present study aimed to quantify the pooled proportion and risk of malarial recurrences after the treatment of Plasmodium-mixed infection. The results of the study may provide benefits in the management of Plasmodium-mixed infection in co-endemic regions.

Efficacy and safety of artemisinin-based combination therapies for the treatment of uncomplicated malaria in pediatrics: a systematic review and meta-analysis

April 14, 2021 - 16:50 -- Open Access
Shibeshi W, Alemkere G, Mulu A, Engidawork E
BMC Infect Dis. 2021 Apr 7;21(1):326

Malaria is a major cause of morbidity and mortality in pediatrics in malaria endemic areas. Artemisinin-based combination therapies (ACTs) are the drugs of choice for malaria management particularly across malaria-endemic countries. This systematic review and meta-analysis was performed to assess efficacy and safety of ACTs for uncomplicated malaria in pediatric populations.

What is the yield of malaria reactive case detection in the Greater Mekong Sub-region? A review of published data and meta-analysis

March 10, 2021 - 14:45 -- Open Access
Jacqueline Deen, Mavuto Mukaka and Lorenz von Seidlein
Malaria Journal 2021 20:131, 4 March 2021

Reactive malaria case detection involves the screening of those in contact with index cases and is used in countries in the Greater Mekong Sub-region. The yield of reactive case detection, defined here as the percentage of positive malaria cases among potential contacts who were screened, was assessed.


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