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meta-analysis

Prevalence of and risk factors for Plasmodium spp. co-infection with hepatitis B virus: a systematic review and meta-analysis

October 15, 2020 - 08:46 -- Open Access
Author(s): 
Kwuntida Uthaisar Kotepui and Manas Kotepui
Reference: 
Malaria Journal 2020 19:368, 15 October 2020

Plasmodium spp. and hepatitis B virus (HBV) are among the most common infectious diseases in underdeveloped countries. This study aimed to determine the prevalence of Plasmodium spp. and HBV co-infection in people living in endemic areas of both diseases and to assess the risk factors related to this co-infection.

Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

September 24, 2020 - 08:09 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, Milanez GJ, Masangkay FR
Reference: 
Infect Dis Poverty. 2020 Sep 22;9(1):134.

Co-infection with both Plasmodium and dengue virus (DENV) infectious species could have serious and fatal outcomes if left undiagnosed and without timely treatment. The present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection, the risk of severe diseases due to co-infection, and to describe the complications of severe malaria and severe dengue among patients with co-infection.

Not Open Access | Global prevalence of congenital malaria: A systematic review and meta-analysis

September 5, 2020 - 15:35 -- NOT Open Access
Author(s): 
Bilal JA, Malik EE, Al-Nafeesah A, Adam I
Reference: 
Eur J Obstet Gynecol Reprod Biol. 2020 Sep;252:534-542

The aim of this systematic review and meta-analysis is to pool the prevalence of congenital malaria.

Epidemiology of clinical congenital and neonatal malaria in endemic settings: a systematic review and meta-analysis

September 1, 2020 - 10:01 -- Open Access
Author(s): 
Celestin Danwang, Jean Joel Bigna, Rolf Nyah Tuku Nzalie and Annie Robert
Reference: 
Malaria Journal 2020 19:312, 28 August 2020

In order to attain the objectives set out in the global technical strategy against malaria 2016–2030, it is important to have accurate epidemiological data on malaria in all age categories, including those which are often neglected because of an apparent low burden of disease. The current systematic review with meta-analysis synthesizes the epidemiology of clinical congenital and neonatal malaria in endemic areas.

Global prevalence and mortality of severe Plasmodium malariae infection: a systematic review and meta-analysis

August 4, 2020 - 15:51 -- Open Access
Author(s): 
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez and Frederick R. Masangkay
Reference: 
Malaria Journal 2020 19:274, 31 July 2020

Severe complications among patients with Plasmodium malariae infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. malariae infection in humans.

Summary of discordant results between rapid diagnosis tests, microscopy, and polymerase chain reaction for detecting Plasmodium mixed infection: a systematic review and meta-analysis

July 30, 2020 - 14:10 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, De Jesus Milanez G, Masangkay FR
Reference: 
Sci Rep. 2020 Jul 29; 10(1):12765

Malaria rapid diagnostic tests (RDTs) are widely used to detect malaria parasites among patients who suspected malaria infections in malaria-endemic areas where microscopy is unavailable. Nevertheless, little is known about the performance of RDTs in detecting Plasmodium mixed infections. The present study aimed to evaluate the discordant results between RDTs and microscopy/polymerase chain reaction (PCR) in detecting Plasmodium mixed infections.

Prevalence of severe Plasmodium knowlesi infection and risk factors related to severe complications compared with non-severe P. knowlesi and severe P. falciparum malaria: a systematic review and meta-analysis

July 30, 2020 - 14:07 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, Milanez GD, Masangkay FR
Reference: 
Infect Dis Poverty. 2020 Jul 29; 9(1):106

Plasmodium knowlesi is a potential cause of severe and fatal malaria, but comprehensive studies of its pooled prevalence and risk factors are lacking. This study aimed to explore the prevalence and risk factors related to severe P. knowlesi infection.

Severity and mortality of severe Plasmodium ovale infection: A systematic review and meta-analysis

June 23, 2020 - 15:38 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, Milanez GD, Masangkay FR
Reference: 
PLoS ONE 15(6): e0235014

Plasmodium ovale can infect humans, causing malaria disease. We aimed to investigate the severity and mortality of severe P. ovale infection to increase the awareness of physicians regarding the prognosis of this severe disease and outcome-related deaths in countries in which this disease is endemic. Articles that were published in the PubMed, Scopus, and ISI Web of Science databases prior to January 5, 2020 and reported the prevalence of severe P. ovale infection were systematically searched and reviewed.

Loop-mediated isothermal amplification (LAMP) test for diagnosis of uncomplicated malaria in endemic areas: a meta-analysis of diagnostic test accuracy

June 22, 2020 - 16:36 -- Open Access
Author(s): 
Denesh Selvarajah, Cho Naing, Norah Htet Htet and Joon Wah Mak
Reference: 
Malaria Journal 2020 19:211, 19 June 2020

The global malaria decline has stalled and only a few countries are pushing towards pre-elimination. The aim of the malaria elimination phase is interruption of local transmission of a specified malaria parasite in a defined geographical area. New and improved screening tools and strategies are required for detection and management of very low-density parasitaemia in the field. The objective of this study was to synthesize evidence on the diagnostic accuracy of loop-mediated isothermal amplification (LAMP) test for the detection of malaria parasites among people living in endemic areas.

Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data

March 10, 2020 - 16:19 -- Open Access
Author(s): 
Chan XHS, Win YN, White NJ, et al.
Reference: 
PLoS Med. 2020 Mar 5;17(3):e1003040

Electrocardiographic QT interval prolongation is the most widely used risk marker for ventricular arrhythmia potential and thus an important component of drug cardiotoxicity assessments. Several antimalarial medicines are associated with QT interval prolongation. However, interpretation of electrocardiographic changes is confounded by the coincidence of peak antimalarial drug concentrations with recovery from malaria. We therefore reviewed all available data to characterise the effects of malaria disease and demographic factors on the QT interval in order to improve assessment of electrocardiographic changes in the treatment and prevention of malaria.

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