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meta-analysis

Randomized trials of housing interventions to prevent malaria and Aedes-transmitted diseases: A systematic review and meta-analysis

January 13, 2021 - 11:28 -- Open Access
Author(s): 
Kua KP, Lee SWH
Reference: 
PLoS One. 2021 Jan 8;16(1):e0244284

Mosquito-borne diseases remain a significant public health problem in tropical regions. Housing improvements such as screening of doors and windows may be effective in reducing disease transmission, but the impact remains unclear.

The association of malaria infection and gestational hypertension in Africa: Systematic review and meta-analysis

December 2, 2020 - 08:32 -- Open Access
Author(s): 
Mruma HA, McQuillan R, Norrie J
Reference: 
J Glob Health. 2020 Dec;10(2):020417

The World Health Organisation (WHO) estimates that hypertensive disorders of pregnancy (HDP) contribute 14% to global maternal mortality. HDP encompasses several subcategories, including gestational hypertension (GH) and pre-eclampsia. These two conditions are both characterised by a rise in blood pressure, with an onset from 20 weeks of gestation. They also share some common risk factors. The current definition of pre-eclampsia includes raised blood pressure in the absence of proteinuria, thus presenting the two conditions as a spectrum. In this article, we refer to both conditions as gestational hypertension, which is our outcome of interest. The aetiology of GH is not yet clearly understood. Observational studies have suggested that malaria may be associated with GH. However, the evidence from these small studies has been inconclusive. Having a better understanding of the association between malaria and GH may help inform prevention strategies to reduce maternal and infant mortality and morbidity.

Efficacy and safety of tafenoquine for malaria chemoprophylaxis (1998-2020): A systematic review and meta-analysis

November 25, 2020 - 12:45 -- Open Access
Author(s): 
Maier JD, Siegfried S, Gültekin N, Stanga Z, Baird JK, Grobusch MP, Schlagenhauf P
Reference: 
Travel Med Infect Dis. 2020 Nov 20:101908

In 2018, tafenoquine was approved for malaria chemoprophylaxis. We evaluated all available data on the safety and efficacy of tafenoquine chemoprophylaxis.

The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis

October 21, 2020 - 08:39 -- Open Access
Author(s): 
Mousa A, Al-Taiar A, Okell LC, et al.
Reference: 
PLoS Med. 2020 Oct 19;17(10):e1003359

Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as ‘test-and-treat’ policies administered by community health workers (CHWs). We conducted a pooled individual-participant meta-analysis to estimate the association between treatment delay and presenting with SM.

Prevalence of and risk factors for Plasmodium spp. co-infection with hepatitis B virus: a systematic review and meta-analysis

October 15, 2020 - 08:46 -- Open Access
Author(s): 
Kwuntida Uthaisar Kotepui and Manas Kotepui
Reference: 
Malaria Journal 2020 19:368, 15 October 2020

Plasmodium spp. and hepatitis B virus (HBV) are among the most common infectious diseases in underdeveloped countries. This study aimed to determine the prevalence of Plasmodium spp. and HBV co-infection in people living in endemic areas of both diseases and to assess the risk factors related to this co-infection.

Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

September 24, 2020 - 08:09 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, Milanez GJ, Masangkay FR
Reference: 
Infect Dis Poverty. 2020 Sep 22;9(1):134.

Co-infection with both Plasmodium and dengue virus (DENV) infectious species could have serious and fatal outcomes if left undiagnosed and without timely treatment. The present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection, the risk of severe diseases due to co-infection, and to describe the complications of severe malaria and severe dengue among patients with co-infection.

Not Open Access | Global prevalence of congenital malaria: A systematic review and meta-analysis

September 5, 2020 - 15:35 -- NOT Open Access
Author(s): 
Bilal JA, Malik EE, Al-Nafeesah A, Adam I
Reference: 
Eur J Obstet Gynecol Reprod Biol. 2020 Sep;252:534-542

The aim of this systematic review and meta-analysis is to pool the prevalence of congenital malaria.

Epidemiology of clinical congenital and neonatal malaria in endemic settings: a systematic review and meta-analysis

September 1, 2020 - 10:01 -- Open Access
Author(s): 
Celestin Danwang, Jean Joel Bigna, Rolf Nyah Tuku Nzalie and Annie Robert
Reference: 
Malaria Journal 2020 19:312, 28 August 2020

In order to attain the objectives set out in the global technical strategy against malaria 2016–2030, it is important to have accurate epidemiological data on malaria in all age categories, including those which are often neglected because of an apparent low burden of disease. The current systematic review with meta-analysis synthesizes the epidemiology of clinical congenital and neonatal malaria in endemic areas.

Global prevalence and mortality of severe Plasmodium malariae infection: a systematic review and meta-analysis

August 4, 2020 - 15:51 -- Open Access
Author(s): 
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez and Frederick R. Masangkay
Reference: 
Malaria Journal 2020 19:274, 31 July 2020

Severe complications among patients with Plasmodium malariae infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. malariae infection in humans.

Summary of discordant results between rapid diagnosis tests, microscopy, and polymerase chain reaction for detecting Plasmodium mixed infection: a systematic review and meta-analysis

July 30, 2020 - 14:10 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, De Jesus Milanez G, Masangkay FR
Reference: 
Sci Rep. 2020 Jul 29; 10(1):12765

Malaria rapid diagnostic tests (RDTs) are widely used to detect malaria parasites among patients who suspected malaria infections in malaria-endemic areas where microscopy is unavailable. Nevertheless, little is known about the performance of RDTs in detecting Plasmodium mixed infections. The present study aimed to evaluate the discordant results between RDTs and microscopy/polymerase chain reaction (PCR) in detecting Plasmodium mixed infections.

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