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NOT Open Access | Increase hemoglobin level in severe malarial anemia while controlling parasitemia: A mathematical model

August 3, 2020 - 16:21 -- NOT Open Access
Author(s): 
Siewe N, Friedman A
Reference: 
Mathematical Biosciences Volume 326, August 2020, 108374

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by immune cells; it can play a protective or deleterious role in response to pathogens. The intracellular malaria parasite secretes a similar protein, PMIF. The present paper is concerned with severe malarial anemia (SMA), where MIF suppresses the recruitment of red blood cells (RBCs) from the spleen and the bone marrow.

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