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cohort study

A diagnostic evaluation of single screen testing for malaria in the returning traveller - a large retrospective cohort study

January 26, 2021 - 15:27 -- Open Access
Reynard C, Geary K, Chiodini P, Brereton M, Burthem J, McDermott J, van den Berg P, Body R
Acad Emerg Med. 2021 Jan 22

Screening for malaria in the returning traveller has often required repeat testing, however audit data suggests that patients have not been re‐attending. We sought to ascertain if this was safe by examining the diagnostic efficacy of a single screen consisting of a rapid‐diagnostic test and a thin film.

NOT Open Access | Association of Malnutrition with Subsequent Malaria Parasitemia among Children Younger than Three years in Kenya: A Secondary Data Analysis of the Asembo Bay Cohort Study

November 18, 2020 - 12:20 -- NOT Open Access
Donovan CV, McElroy P, Adair L, Pence BW, Oloo AJ, Lal A, Bloland P, Nahlen B, Juliano JJ, Meshnick S
Am J Trop Med Hyg. 2020 Nov 16

Malaria and malnutrition remain primary causes of morbidity and mortality among children younger than 5 years in Africa. Studies investigating the association between malnutrition and subsequent malaria outcomes are inconsistent. We studied the effects of malnutrition on incidence and prevalence of malaria parasitemia in data from a cohort studied in the 1990s.

Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo

November 12, 2020 - 15:53 -- Open Access
Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Paul Krezanoski, John Rek, Victor Kamya, Adrienne Epstein, Philip J. Rosenthal, Chris Drakeley, Moses R. Kamya, Grant Dorsey and Sarah G. Staedke
Malaria Journal 2020 19:405, 11 November 2020

The burden of malaria in Uganda remains high, but has become increasingly heterogenous following intensified malaria control. Travel within Uganda is recognized as a risk factor for malaria, but behaviours associated with travel are not well-understood. To address this knowledge gap, malaria-relevant behaviours of cohort participants were assessed during travel and at home in Uganda.

Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study

October 1, 2020 - 15:22 -- Open Access
Batte A, Starr MC, Schwaderer AL, Opoka RO, Namazzi R, Phelps Nishiguchi ES, Ssenkusu JM, John CC, Conroy AL
BMC Nephrol. 2020 Sep 29;21(1):417

Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate baseline creatinine (bSCr) are not standardized in this unique patient population. Prior to wide-spread utilization, bSCr estimation methods need to be evaluated in many populations, particularly in children from low-income countries.

The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study

February 25, 2020 - 16:04 -- Open Access
Dini S, Douglas NM, Poespoprodjo JR, Kenangalem E, Sugiarto P, Plumb ID, Price RN, Simpson JA
BMC Med. 2020 Feb 20;18(1):28

An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a partially treated parasite or, in the case of Plasmodium vivax or P. ovale, relapse from the dormant liver stage of the parasite. The aim of this study was to quantify the impact of recurrent malaria episodes on morbidity and mortality in Papua, Indonesia.

Diagnosis of pneumonia and malaria in Nigerian hospitals: A prospective cohort study

February 24, 2020 - 14:21 -- Open Access
Graham H, Bakare AA, Ayede AI, Oyewole OB, Gray A, Neal E, Qazi SA, Duke T, Falade AG
Pediatr Pulmonol. 2020 Feb 19

Pneumonia and malaria are the leading causes of global childhood mortality. We describe the clinical presentation of children diagnosed with pneumonia and/or malaria, and identify possible missed cases and diagnostic predictors.

The effectiveness of older insecticide-treated bed nets (ITNs) to prevent malaria infection in an area of moderate pyrethroid resistance: results from a cohort study in Malawi

January 20, 2020 - 15:44 -- Open Access
Monica P. Shah, Laura C. Steinhardt, Dyson Mwandama, Themba Mzilahowa, John E. Gimnig, Andy Bauleni, Jacklyn Wong, Ryan Wiegand, Don P. Mathanga and Kim A. Lindblade
Malaria Journal 2020 19:24, 15 January 2020

A previous cohort study in Malawi showed that users of new insecticide-treated bed nets (ITNs) were significantly protected against malaria compared to non-users, despite moderate levels of pyrethroid resistance among the primary mosquito vectors. The present study investigated whether ITNs that were 1–2 years old continued to protect users in the same area with moderate pyrethroid resistance.

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

January 20, 2020 - 15:27 -- Open Access
Elijah Kakande, Bryan Greenhouse, Isabel Rodriguez-Barraquer, et al.
Malaria Journal 2020 19:21, 15 January 2020

Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear.

Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study

October 14, 2019 - 15:22 -- Open Access
Robyn E. Elphinstone, Andrea M. Weckman, Kevin C. Kain, et al.
PLoS Med 16(10): e1002914

Malaria in pregnancy is associated with adverse birth outcomes. However, the underlying mechanisms remain poorly understood. Tight regulation of angiogenic, metabolic, and inflammatory pathways are essential for healthy pregnancies. We hypothesized that malaria disrupts these pathways leading to preterm birth (PTB).

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