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transmission blocking

Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening

February 11, 2021 - 09:21 -- Open Access
Author(s): 
Fabbri C, Trindade AO, Andrade FS, Souza MF, Ríos-Velásquez CM, Lacerda MVG, Monteiro WM, Costa FTM, Amino R, Lopes SCP
Reference: 
Mem Inst Oswaldo Cruz. 2021 Feb 8;116:e200513

Different strategies for improvement of malaria control and elimination are based on the blockage of malaria parasite transmission to the mosquito vector. These strategies include the drugs that target the plasmodial sexual stages in humans and the early developmental stages inside mosquitoes.

Evaluation and modeling of direct membrane-feeding assay with Plasmodium vivax to support development of transmission blocking vaccines

July 30, 2020 - 13:29 -- Open Access
Author(s): 
Miura K, Swihart BJ, Fay MP, Kumpitak C, Kiattibutr K, Sattabongkot J, Long CA
Reference: 
Sci Rep. 2020 Jul 28;10(1):12569

Standard and direct membrane-feeding assays (SMFA and DMFA) are fundamental assays to evaluate efficacy of transmission-blocking intervention (TBI) candidates against Plasmodium falciparum and vivax. To compare different candidates precisely, it is crucial to understand the error range of measured activity, usually expressed as percent inhibition in either oocyst intensity (% transmission reducing activity, %TRA), or in prevalence of infected mosquitoes (% transmission blocking activity, %TBA).

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