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γẟ T cells

NOT Open ACcess | γẟ T cells in malaria: a double edged sword

July 27, 2020 - 15:04 -- NOT Open Access
Author(s): 
Pamplona A, Silva-Santos B
Reference: 
FEBS J. 2020 Jul 24

Malaria remains a devastating global health problem, resulting in many annual deaths due to the complications of severe malaria. However, in endemic regions, individuals can acquire "clinical immunity" to malaria, characterized by a decrease in severe malaria episodes and an increase of asymptomatic Plasmodium falciparum infections. Recently, it has been reported that tolerance to "clinical malaria" and reduced disease severity correlates with a decrease in the numbers of circulating Vγ9Vδ2 T cells, the major subset of γδ T cells in the human peripheral blood.

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