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anti-phosphatidylserine

Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections

July 21, 2020 - 15:15 -- Open Access
Author(s): 
Rivera-Correa J, Yasnot-Acosta MF, Tovar NC, Velasco-Pareja MC, Easton A, Rodriguez A
Reference: 
PLoS Negl Trop Dis 14(7): e0008466

Malaria caused by Plasmodium vivax is a highly prevalent infection world-wide, that was previously considered mild, but complications such as anemia have been highly reported in the past years. In mice models of malaria, anti-phosphatidylserine (anti-PS) autoantibodies, produced by atypical B-cells, bind to uninfected erythrocytes and contribute to anemia. In human patients with P. falciparum malaria, the levels of anti-PS, atypical B-cells and anemia are strongly correlated to each other.

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