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NOT Open Access | Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with Plasmodium berghei

June 8, 2020 - 14:49 -- NOT Open Access
Author(s): 
Ayankunle A, Wakeel O, Kolawole O, Oyekale A, Ojurongbe O, Adeyeba O
Reference: 
Cent Nerv Syst Agents Med Chem. 2020 Jun 4

Drug repositioning is becoming popular due to the development of resistance to almost all the recommended antimalarials. Pregabalin and gabapentin are chemical analogs of gamma-aminobutyric acid (GABA) approved for the treatment of epilepsy and neuropathic pain.

NOT Open Access | The C-terminal region of the Plasmodium yoelii microgamete surface antigen PyMiGS induces potent anti-malarial transmission-blocking immunity in mice

March 17, 2020 - 12:55 -- NOT Open Access
Author(s): 
Tachibana M, Baba M, Takashima E, Tsuboi T, Torii M, Ishino T
Reference: 
Vaccine Volume 38, Issue 15, 30 March 2020, Pages 3129-3136

Malaria transmission-blocking vaccines (TBVs) aim to inhibit parasite fertilization or further development within the mosquito midgut. Because TBV-immunized individuals reduce the transmission of malaria parasites to mosquito vectors, TBVs could serve as a promising strategy to eliminate malaria.

NOT Open Access | Combination of zingerone and dihydroartemisinin presented synergistic antimalarial activity against Plasmodium berghei infection in BALB/c mice as in vivo model

March 2, 2020 - 14:07 -- NOT Open Access
Author(s): 
Ounjaijean S, Somsak V
Reference: 
Parasitology International, 20 February 2020, 102088

Malaria is a global health problem leading to the death of 435,000 cases in tropical and sub-tropical zones. Spread and emergence of increasing resistance to the antimalarial drugs are the major challenges in the control of malaria. Therefore, searching for alternative antimalarial drugs is urgently needed, and combination treatment preferred as an approach to address this. This study aimed to evaluate in vivo antimalarial activity of zingerone (ZN), and its combination with dihydroartemisinin (DHA) against Plasmodium berghei infected mice.

NOT Open Access | Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice

January 15, 2020 - 09:12 -- NOT Open Access
Author(s): 
Ssemaganda A, Giddam AK, Low LM, Liu XQ, Ho MF, Zaman M, Hussein WM, Skwarczynski M, Toth I, Stanisic DI, Good MF
Reference: 
Vaccine, 2019 Dec 19. pii: S0264-410X(19)31617-2

The development of a blood-stage malaria vaccine has largely focused on the subunit approach. However, the limited success of this strategy, mainly due to antigenic polymorphism and the failure to maintain potent parasite-specific immune responses, indicates that other approaches must be considered. Whole parasite (WP) vaccines offer many advantages over sub-units; they represent every antigen on the organism, thus limiting the effects of antigenic polymorphism, and similarly they compensate for individual Immune-Response (Ir) gene-regulated non-responsiveness to any particular antigen. From a development perspective, they negate the need to identify and compare the relative efficacies of individual candidate antigens. WP vaccines induce protective immunity that is largely cell-mediated.

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

December 30, 2019 - 14:23 -- Open Access
Author(s): 
Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Rusliza Basir, et al.
Reference: 
Malaria Journal 2019 18:434, 19 December 2019

The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during malaria infection, the study aimed to characterize the expression and functional contribution(s) of IL-35 in Plasmodium berghei (strain ANKA) infected mice.

Tamoxifen activity against Plasmodium in vitro and in mice

December 3, 2019 - 15:24 -- Open Access
Author(s): 
Ada Weinstock, Julio Gallego-Delgado, Cláudia Gomes, Julian Sherman, Cyrus Nikain, Sandra Gonzalez, Edward Fisher and Ana Rodriguez
Reference: 
Malaria Journal 2019 18:378, 27 November 2019

Tamoxifen is an oestrogen receptor modulator that is widely used for the treatment of early stage breast cancer and reduction of recurrences. Tamoxifen is also used as a powerful research tool for controlling gene expression in the context of the Cre/loxP site-specific recombination system in conditional mutant mice.

Trypanosoma brucei infection protects mice against malaria

November 12, 2019 - 16:10 -- Open Access
Author(s): 
Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M.
Reference: 
PLoS Pathog. 2019 Nov 8;15(11):e1008145

Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness, would inhibit a subsequent infection by Plasmodium, the malaria parasite, decreasing the severity of its associated pathology.

Medical Condition: 

NOT Open Access | Potential role of arteether on N-methyl-D-aspartate (NMDA) receptor expression in experimental cerebral malaria mice and extension of their survival

October 8, 2019 - 15:38 -- NOT Open Access
Author(s): 
Sunil Kumar Singh, Hemlata Dwivedi, Sarika Gunjan, Bhavana Singh Chauhan, Swaroop Kumar Pandey, Renu Tripathi
Reference: 
Parasitology, Volume 146, Issue 12, October 2019, pp. 1571-1577

Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries.

Medical Condition: 
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