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mice

NOT Open Access | Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice

September 23, 2020 - 09:36 -- NOT Open Access
Author(s): 
Wang W, Yao J, Chen Z, Sun Y, Shi Y, Wei Y, Zhou H, Yu Y, Li S, Duan L
Reference: 
Br J Pharmacol. 2020 Sep 22

Malaria is one of the deadliest diseases in the world. Novel chemotherapeutic agents are urgently required to combat the widespread Plasmodium resistance to frontline drugs. Here, we report the discovery of a novel benzonaphthyridine antimalarial, methnaridine, which was identified using a structural optimization strategy.

A Plasmodium cysteine protease required for efficient transition from the liver infection stage

September 23, 2020 - 08:55 -- Open Access
Author(s): 
Putrianti ED, Schmidt-Christensen A, Heussler V, Matuschewski K, Ingmundson A
Reference: 
PLoS Pathog. 2020 Sep 21;16(9):e1008891

The transitions between developmental stages are critical points in the Plasmodium life cycle. The development of Plasmodium in the livers of their mammalian hosts bridges malaria transmission and the onset of clinical symptoms elicited by red blood cell infection. The egress of Plasmodium parasites from the liver must be a carefully orchestrated process to ensure a successful switch to the blood stage of infection.

NOT Open Access | Humanized Mice and the Rebirth of Malaria Genetic Crosses

September 15, 2020 - 15:07 -- NOT Open Access
Author(s): 
Vendrely KM, Kumar S, Li X, Vaughan AM
Reference: 
Trends Parasitol. 2020 Sep 2:S1471-4922(20)30192-6

The first experimental crosses carried out with the human malaria parasite Plasmodium falciparum played a key role in determining the genetic loci responsible for drug resistance, virulence, invasion, growth rate, and transmission.

Trichinella spiralis co-infection exacerbates Plasmodium berghei malaria-induced hepatopathy

September 12, 2020 - 15:12 -- Open Access
Author(s): 
Mei X, Ye Z, Chang Y, Huang S, Song J, Lu F
Reference: 
Parasit Vectors. 2020 Sep 3;13(1):440

Although Plasmodium parasites and intestinal helminths share common endemic areas, the mechanisms of these co-infections on the host immune response remain not fully understood. Liver involvement in severe Plasmodium falciparum infections is a significant cause of morbidity and mortality. However, the effect of pre-existing Trichinella spiralis infection on the immune response and liver immune-pathogenesis in P. berghei ANKA (PbANKA)-infected mice needs to be elucidated.

Not Open Access | Measuring of IgG2c isotype instead of IgG2a in immunized C57BL/6 mice with Plasmodium vivax TRAP as a subunit vaccine candidate in order to correct interpretation of Th1 versus Th2 immune response

September 5, 2020 - 15:36 -- NOT Open Access
Author(s): 
Nazeri S, Zakeri S, Mehrizi AA, Sardari S, Djadid ND
Reference: 
Exp Parasitol. 2020 Sep;216:107944

Evaluation of the murine isotype antibodies is essential in subunit vaccine development because inbred mouse strains with diverse genetic backgrounds respond different to recombinant proteins. In this regard, the main goal of this study was to measuring and comparing the profile of IgG isotype responses in C57BL/6 mice. For this purpose, the extracellular region of plasmodium vivax thrombospondin-related adhesive protein (PvTRAP) gene was expressed in Escherichia coli Rosetta (DE3)-pET23a.

NOT Open Access | Evidence of Microbiome-Drug Interactions between the Antimalarial Lumefantrine and Gut Microbiota in Mice

July 7, 2020 - 13:02 -- NOT Open Access
Author(s): 
Ippolito MM, Denny JE, Nenortas E, Shapiro TA, Schmidt NW
Reference: 
Am J Trop Med Hyg. 2020 Jul 6

The antimalarial drug lumefantrine (LF) exhibits erratic pharmacokinetics (PK). Intersubject variability might be attributed, in part, to differences in the gut microbiome-mediated drug metabolism. We assessed LF disposition in healthy mice stratified by enterotype to explore associations between the gut microbiota and LF PK. Gut microbiota enterotypes were classified according to abundance and diversity indices from 16S rRNA sequencing.

NOT Open Access | Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with Plasmodium berghei

June 8, 2020 - 14:49 -- NOT Open Access
Author(s): 
Ayankunle A, Wakeel O, Kolawole O, Oyekale A, Ojurongbe O, Adeyeba O
Reference: 
Cent Nerv Syst Agents Med Chem. 2020 Jun 4

Drug repositioning is becoming popular due to the development of resistance to almost all the recommended antimalarials. Pregabalin and gabapentin are chemical analogs of gamma-aminobutyric acid (GABA) approved for the treatment of epilepsy and neuropathic pain.

NOT Open Access | The C-terminal region of the Plasmodium yoelii microgamete surface antigen PyMiGS induces potent anti-malarial transmission-blocking immunity in mice

March 17, 2020 - 12:55 -- NOT Open Access
Author(s): 
Tachibana M, Baba M, Takashima E, Tsuboi T, Torii M, Ishino T
Reference: 
Vaccine Volume 38, Issue 15, 30 March 2020, Pages 3129-3136

Malaria transmission-blocking vaccines (TBVs) aim to inhibit parasite fertilization or further development within the mosquito midgut. Because TBV-immunized individuals reduce the transmission of malaria parasites to mosquito vectors, TBVs could serve as a promising strategy to eliminate malaria.

NOT Open Access | Combination of zingerone and dihydroartemisinin presented synergistic antimalarial activity against Plasmodium berghei infection in BALB/c mice as in vivo model

March 2, 2020 - 14:07 -- NOT Open Access
Author(s): 
Ounjaijean S, Somsak V
Reference: 
Parasitology International, 20 February 2020, 102088

Malaria is a global health problem leading to the death of 435,000 cases in tropical and sub-tropical zones. Spread and emergence of increasing resistance to the antimalarial drugs are the major challenges in the control of malaria. Therefore, searching for alternative antimalarial drugs is urgently needed, and combination treatment preferred as an approach to address this. This study aimed to evaluate in vivo antimalarial activity of zingerone (ZN), and its combination with dihydroartemisinin (DHA) against Plasmodium berghei infected mice.

NOT Open Access | Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice

January 15, 2020 - 09:12 -- NOT Open Access
Author(s): 
Ssemaganda A, Giddam AK, Low LM, Liu XQ, Ho MF, Zaman M, Hussein WM, Skwarczynski M, Toth I, Stanisic DI, Good MF
Reference: 
Vaccine, 2019 Dec 19. pii: S0264-410X(19)31617-2

The development of a blood-stage malaria vaccine has largely focused on the subunit approach. However, the limited success of this strategy, mainly due to antigenic polymorphism and the failure to maintain potent parasite-specific immune responses, indicates that other approaches must be considered. Whole parasite (WP) vaccines offer many advantages over sub-units; they represent every antigen on the organism, thus limiting the effects of antigenic polymorphism, and similarly they compensate for individual Immune-Response (Ir) gene-regulated non-responsiveness to any particular antigen. From a development perspective, they negate the need to identify and compare the relative efficacies of individual candidate antigens. WP vaccines induce protective immunity that is largely cell-mediated.

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