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NOT Open Access | Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice

January 15, 2020 - 09:12 -- NOT Open Access
Ssemaganda A, Giddam AK, Low LM, Liu XQ, Ho MF, Zaman M, Hussein WM, Skwarczynski M, Toth I, Stanisic DI, Good MF
Vaccine, 2019 Dec 19. pii: S0264-410X(19)31617-2

The development of a blood-stage malaria vaccine has largely focused on the subunit approach. However, the limited success of this strategy, mainly due to antigenic polymorphism and the failure to maintain potent parasite-specific immune responses, indicates that other approaches must be considered. Whole parasite (WP) vaccines offer many advantages over sub-units; they represent every antigen on the organism, thus limiting the effects of antigenic polymorphism, and similarly they compensate for individual Immune-Response (Ir) gene-regulated non-responsiveness to any particular antigen. From a development perspective, they negate the need to identify and compare the relative efficacies of individual candidate antigens. WP vaccines induce protective immunity that is largely cell-mediated.

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

December 30, 2019 - 14:23 -- Open Access
Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Rusliza Basir, et al.
Malaria Journal 2019 18:434, 19 December 2019

The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during malaria infection, the study aimed to characterize the expression and functional contribution(s) of IL-35 in Plasmodium berghei (strain ANKA) infected mice.

Tamoxifen activity against Plasmodium in vitro and in mice

December 3, 2019 - 15:24 -- Open Access
Ada Weinstock, Julio Gallego-Delgado, Cláudia Gomes, Julian Sherman, Cyrus Nikain, Sandra Gonzalez, Edward Fisher and Ana Rodriguez
Malaria Journal 2019 18:378, 27 November 2019

Tamoxifen is an oestrogen receptor modulator that is widely used for the treatment of early stage breast cancer and reduction of recurrences. Tamoxifen is also used as a powerful research tool for controlling gene expression in the context of the Cre/loxP site-specific recombination system in conditional mutant mice.

Trypanosoma brucei infection protects mice against malaria

November 12, 2019 - 16:10 -- Open Access
Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M.
PLoS Pathog. 2019 Nov 8;15(11):e1008145

Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness, would inhibit a subsequent infection by Plasmodium, the malaria parasite, decreasing the severity of its associated pathology.

Medical Condition: 

NOT Open Access | Potential role of arteether on N-methyl-D-aspartate (NMDA) receptor expression in experimental cerebral malaria mice and extension of their survival

October 8, 2019 - 15:38 -- NOT Open Access
Sunil Kumar Singh, Hemlata Dwivedi, Sarika Gunjan, Bhavana Singh Chauhan, Swaroop Kumar Pandey, Renu Tripathi
Parasitology, Volume 146, Issue 12, October 2019, pp. 1571-1577

Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries.

Medical Condition: 
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