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male gametogenesis

NOT Open Access | A conserved malaria parasite antigen Pb22 plays a critical role in male gametogenesis in Plasmodium berghei

November 25, 2020 - 11:54 -- NOT Open Access
Liu F, Yang F, Wang Y, Hong M, Zheng W, Min H, Li D, Jin Y, Tsuboi T, Cui L, Cao Y
Cell Microbiol. 2020 Nov 22:e13294

Gametogenesis, the formation of gametes from gametocytes, an essential step for malaria parasite transmission, is targeted by transmission-blocking drugs and vaccines. We identified a conserved protein (PBANKA_0305900) in Plasmodium berghei, which encodes a protein of 22 kDa (thus named Pb22) and is expressed in both asexual stages and gametocytes. Its homologs are present in all Plasmodium species and its closely related Hepatocystis, but not in other apicomplexans. Pb22 protein was localized in the cytosols of schizonts, as well as male and female gametocytes.

PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum

July 20, 2020 - 16:08 -- Open Access
Hitz E, Balestra AC, Brochet M, Voss TS
Sci Rep. 2020 Jul 17;10(1):11930

In malaria parasites, male gametogenesis is a proliferative stage essential for parasite transmission to the mosquito vector. It is a rapid process involving three rounds of genome replication alternating with closed endomitoses, and assembly of axonemes to produce eight flagellated motile microgametes. Studies in Plasmodium berghei have highlighted tight regulation of gametogenesis by a network of kinases.

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