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clinical trials

Hydroxychloroquine Controversies: Clinical Trials, Epistemology, and the Democratization of Science

November 19, 2020 - 13:23 -- Open Access
Tags: 
Covid-19, antimalarial drugs, Hydroxychloroquine, clinical trials, epistemology
Author(s): 
Berlivet L, Löwy I
Reference: 
Med Anthropol Q. 2020 Nov 18

The claim that anti-malaria drugs, chloroquine and hydroxychloroquine, can cure COVID-19 became a focus of fierce political battles that pitted promoters of these pharmaceuticals, Presidents Bolsonaro and Trump among them, against "medical elites." At the center of these battles are different meanings of effectiveness in medicine, the complex role of randomized clinical trials (RCTs) in proving such effectiveness, the task of medical experts and the state in regulating pharmaceuticals, patients' activism, and the collective production of medical knowledge.

NOT Open Access | Decreased Mortality of falciparum Malaria in Anemic Prisoners of War

September 10, 2020 - 08:46 -- NOT Open Access
Tags: 
falciparum, malaria, clinical trials, Army soldiers, Asia, Papua New Guinea
Author(s): 
Shanks GD
Reference: 
Am J Trop Med Hyg. 2020 Sep 8

Modern clinical trials have suggested that anemia protects against malaria mortality. Military records of the Second World War in Asia were examined to see if there was support for this hypothesis. When relatively well-nourished Imperial Japanese Navy sailors captured on Nauru (n = 799) were imprisoned on the Fauro Islands, 26% died from falciparum malaria.

NOT Open Access | Communities and Clinical Trials: A Case Study from the RTS,S Malaria Vaccine Trials in Eastern Africa

August 31, 2020 - 15:06 -- NOT Open Access
Tags: 
clinical trials, malaria, vaccine, Eastern Africa
Author(s): 
Wyss-van den Berg M, Ogutu B, Sewankambo NK, Merten S, Biller-Andorno N, Tanner M
Reference: 
J Empir Res Hum Res Ethics. 2020 Aug 26:1556264620951384

When clinical trials enter human communities, two complex systems merge-creating challenges for the clinical trial team and the local human community. This is of particular relevance for clinical trials in low-resource settings where the resource scarcity can intensify existing inequities. Here we present a case study of a phase III malaria vaccine clinical trial.

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

July 20, 2020 - 15:55 -- Open Access
Tags: 
plasmodium falciparum, malaria, clinical trials, molecular epidemiology, resistance, antimalarial drugs, Greater Mekong Subregion
Author(s): 
Imwong M, Dhorda M, White NJ, et al.
Reference: 
Lancet Infect Dis. 2020 Jul 14:S1473-3099(20)30228-0

The Greater Mekong subregion is a recurrent source of antimalarial drug resistance in Plasmodium falciparum malaria. This study aimed to characterise the extent and spread of resistance across this entire region between 2007 and 2018.

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