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Structural insights

NOT Open Access | The multifaceted histone chaperone RbAp46/48 in Plasmodium falciparum: structural insights, production, and characterization

May 6, 2020 - 15:42 -- NOT Open Access
Kaushik M, Nehra A, Gakhar SK, Gill SS, Gill R
Parasitol Res. 2020 May 4

RbAp46/RBBP7 and RbAp48/RBBP4 are WD40-repeat histone chaperones and chromatin adaptors that reside in multiple complexes involved in maintenance of chromatin structure. RbAp48 is the essential subunit of the chromatin assembly factor-1 (CAF-1) complex, therefore also named as CAF-1C. A detailed in silico sequence and structure analysis of homologs of RbAp46/48 in Plasmodium falciparum (PF3D7_0110700 and PF3D7_1433300) exhibited conservation of characteristic features in both the protein-seven-bladed WD40 β-propeller conformation and different binding interfaces.

Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

October 8, 2019 - 15:36 -- Open Access
Frank Lennartz, Cameron Smith, Alister G. Craig, and Matthew K. Higgins
PNAS October 1, 2019 116 (40) 20124-20134

A major determinant of pathogenicity in malaria caused by Plasmodium falciparum is the adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected individuals.

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