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artemether-lumefantrine treatment

Electrocardiographic safety evaluation of extended artemether-lumefantrine treatment in patients with uncomplicated Plasmodium falciparum malaria in Bagamoyo District, Tanzania

July 15, 2020 - 15:11 -- Open Access
Author(s): 
Lwidiko E. Mhamilawa, Sven Wikström, Bruno P. Mmbando, Billy Ngasala and Andreas Mårtensson
Reference: 
Malaria Journal 2020 19:250, 14 July 2020

Extended artemisinin-based combination therapy (ACT) for treatment of uncomplicated Plasmodium falciparum malaria with already existing drug regimens, such as artemether-lumefantrine, might be effective in tackling the emerging ACT resistance. However, given the history of cardiotoxicity among anti-malarial drugs structurally similar to lumefantrine, the potential effect of extended artemether-lumefantrine treatment on the electrocardiographic (ECG) QTc interval is of high concern.

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