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parasite isolates

Plasmodium vivax HAP2/GCS1 gene exhibits limited genetic diversity among parasite isolates from the Greater Mekong Subregion

April 13, 2020 - 13:55 -- Open Access
Author(s): 
Li D, Yu C, Cao Y, et al.
Reference: 
Parasit Vectors. 2020 Apr 7;13(1):175

Antigens expressed in sexual stages of the malaria parasites are targets of transmission-blocking vaccines (TBVs). HAP2/GCS1, a TBV candidate, is critical for fertilization in Plasmodium. Here, the genetic diversity of PvHAP2 was studied in Plasmodium vivax parasite populations from the Greater Mekong Subregion (GMS).

Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine

October 8, 2019 - 15:12 -- Open Access
Author(s): 
Moses N. Ikegbunam, Charles N. Nkonganyi, Bolaji N. Thomas, Charles O. Esimone, Thirumalaisamy P. Velavan and Olusola Ojurongbe
Reference: 
Malaria Journal 2019 18:343, 7 October 2019

A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria.

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