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parasite histones

Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria

July 15, 2020 - 14:22 -- Open Access
Author(s): 
Moxon CA, Alhamdi Y, Storm J, Toh CH, et al.
Reference: 
Blood Adv. 2020 Jul 14; 4(13):2851-2864

Microvascular thrombosis and blood-brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling. How Plasmodium falciparum infection causes this endothelial disruption and why this occurs, particularly in the brain, is not fully understood. In this study, we have demonstrated that circulating extracellular histones, equally of host and parasite origin, are significantly elevated in CM patients. Higher histone levels are associated with brain swelling on magnetic resonance imaging.

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