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NOT Open Access | Synthesis and structure-activity relationships of new chiral spiro-beta-lactams highly active against HIV-1 and Plasmodium

July 6, 2021 - 13:06 -- NOT Open Access
Alves NG, Bártolo I, Pinho E Melo TMVD, et al.
Eur J Med Chem. 2021 Jul 5;219:113439

The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penicillanates with dual activity against HIV and Plasmodium.

NOT Open Access | Repurposing of well-known medications as antivirals: hydroxychloroquine and chloroquine; from HIV-1 infection to COVID-19

July 7, 2020 - 14:01 -- NOT Open Access
Naghipour S, Ghodousi M, Rahsepar S, Elyasi S
Expert Rev Anti Infect Ther. 2020 Jul 7

Chloroquine (CQ) and hydroxychloroquine (HCQ), originally were prescribed for prevention or treatment of malaria, but now successfully are used in several rheumatologic diseases. In addition, in recent decades considering their immunomodulatory effects, high tolerably and low cost, they are evaluated for various viral infections from HIV to COVID-19.

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