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clinical samples

Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure

July 6, 2020 - 16:52 -- Open Access
Ibrahim A, Diez Benavente E, Campino S, et al.
Sci Rep. 2020 Jul 2;10(1):10832

The genomic diversity of Plasmodium malariae malaria parasites is understudied, partly because infected individuals tend to present with low parasite densities, leading to difficulties in obtaining sufficient parasite DNA for genome analysis. Selective whole genome amplification (SWGA) increases the relative levels of pathogen DNA in a clinical sample, but has not been adapted for P. malariae parasites.

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