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CD8(+) T cells

Not Open Access | Memory CD8(+) T cells exhibit tissue imprinting and non-stable exposure-dependent reactivation characteristics following blood-stage Plasmodium berghei ANKA infections

August 25, 2021 - 15:48 -- NOT Open Access
Shaw TN, Haley MJ, Dookie RS, Godfrey JJ, Cheeseman AJ, Strangward P, Zeef LAH, Villegas-Mendez A, Couper KN
Immunology. 2021 Aug 18

Experimental cerebral malaria (ECM) is a severe complication of Plasmodium berghei ANKA (PbA) infection in mice, characterised by CD8+ T cell accumulation within the brain. Whilst the dynamics of CD8+ T cell activation and migration during extant primary PbA infection have been extensively researched, the fate of the parasite-specific CD8+ T cells upon resolution of ECM are not understood. In this study we show that memory OT-I cells persist systemically within the spleen, lung and brain following recovery from ECM after primary PbA-OVA infection.

Not Open Access | Glycolipid-peptide vaccination induces liver-resident memory CD8(+) T cells that protect against rodent malaria

June 30, 2020 - 14:30 -- NOT Open Access
Holz LE, Chua YC, Heath WR, et al.
Science Immunology 26 Jun 2020: Vol. 5, Issue 48, eaaz8035

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vaccines for generating this important immune population are lacking. Here, we report the development of a fully synthetic self-adjuvanting glycolipid-peptide conjugate vaccine designed to efficiently induce liver TRM cells.

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