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glycolipid-peptide vaccination

Not Open Access | Glycolipid-peptide vaccination induces liver-resident memory CD8(+) T cells that protect against rodent malaria

June 30, 2020 - 14:30 -- NOT Open Access
Holz LE, Chua YC, Heath WR, et al.
Science Immunology 26 Jun 2020: Vol. 5, Issue 48, eaaz8035

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vaccines for generating this important immune population are lacking. Here, we report the development of a fully synthetic self-adjuvanting glycolipid-peptide conjugate vaccine designed to efficiently induce liver TRM cells.

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