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NOT Open Access | Lipid Compositions in Infant Formulas Affect the Solubilization of Antimalarial Drugs Artefenomel (OZ439) and Ferroquine during Digestion

June 26, 2020 - 15:27 -- NOT Open Access
Salim M, Ramirez G, Peng KY, Clulow AJ, Hawley A, Ramachandruni H, Beilles S, Boyd BJ
Mol Pharm. 2020 Jun 23q

Recent studies have shown that the solubilization of two antimalarial drug candidates, artefenomel (OZ439) and ferroquine (FQ), designed to provide a single-dose combination therapy for uncomplicated malaria can be enhanced using milk as a lipid-based formulation. However, milk as an excipient faces significant quality and regulatory hurdles.

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