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ntimalarial drugs

NOT Open Access | Lipid Compositions in Infant Formulas Affect the Solubilization of Antimalarial Drugs Artefenomel (OZ439) and Ferroquine during Digestion

June 26, 2020 - 15:27 -- NOT Open Access
Author(s): 
Salim M, Ramirez G, Peng KY, Clulow AJ, Hawley A, Ramachandruni H, Beilles S, Boyd BJ
Reference: 
Mol Pharm. 2020 Jun 23q

Recent studies have shown that the solubilization of two antimalarial drug candidates, artefenomel (OZ439) and ferroquine (FQ), designed to provide a single-dose combination therapy for uncomplicated malaria can be enhanced using milk as a lipid-based formulation. However, milk as an excipient faces significant quality and regulatory hurdles.

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