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NOT Open Access | Letter Regarding Kamau et al: 2021 Safety and Tolerability of Mosquito-Bite Induced Controlled Human Infection with P. vivax in Malaria-Naive Study Participants - Clinical Profile and Utility of Molecular Diagnostic Methods

October 16, 2021 - 11:56 -- NOT Open Access
Odedra A, Woodford J, Chalon S, Barber BE, McCarthy JS
J Infect Dis. 2021 Oct 5:jiab502

No abstract available

IMRAS-A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents

June 23, 2020 - 15:15 -- Open Access
Hickey B, Teneza-Mora N, Epstein JE, et al.
PLoS ONE 15(6): e0233840

Immunization with radiation-attenuated sporozoites (RAS) by mosquito bite provides >90% sterile protection against Plasmodium falciparum (Pf) malaria in humans. RAS invade hepatocytes but do not replicate. CD8+ T cells recognizing parasite-derived peptides on the surface of infected hepatocytes are likely the primary protective mechanism. We conducted a randomized clinical trial of RAS immunization to assess safety, to achieve 50% vaccine efficacy (VE) against controlled human malaria infection (CHMI), and to generate reagents from protected and non-protected subjects for future identification of protective immune mechanisms and antigens.

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