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human leukocyte antigens (HLAs)

Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria

June 17, 2020 - 12:57 -- Open Access
Tukwasibwe S, Nakimuli A, Colucci F, et al.
Cell Mol Immunol. 2020 Jun 15

Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocytic Plasmodium falciparum parasites by cytolysis, and participate in the initiation and development of adaptive immune responses to plasmodial infection.

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