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antibody response

Human exposure to Anopheles farauti bites in the Solomon Islands is not associated with IgG antibody response to the gSG6 salivary protein of Anopheles gambiae

October 7, 2019 - 15:20 -- Open Access
Author(s): 
Edgar J. M. Pollard, Catriona Patterson, Tanya L. Russell, Alan Apairamo, Jance Oscar, Bruno Arcà, Chris Drakeley and Thomas R. Burkot
Reference: 
Malaria Journal 2019 18:334, 1 October 2019

Mosquito saliva elicits immune responses in humans following mosquito blood feeding. Detection of human antibodies recognizing the Anopheles gambiae salivary gland protein 6 (gSG6) or the gSG6-P1 peptide in residents of Africa, South America and Southeast Asia suggested the potential for these antibodies to serve as a universal marker to estimate human biting rates. Validating the utility of this approach requires concurrent comparisons of anopheline biting rates with antibodies to the gSG6 protein to determine the sensitivity and specificity of the assay for monitoring changes in vector populations. This study investigated whether seroprevalence of anti-gSG6 antibodies in humans reflected the relative exposure to Anopheles farauti bites in the Solomon Islands as estimated from sympatric human landing catches.

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