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circumsporozoite surface protein

Circumsporozoite Surface Protein-based malaria vaccines: a review

February 6, 2021 - 10:47 -- Open Access
Almeida MEM, Vasconcelos MGS, Tarragô AM, Mariúba LAM
Rev Inst Med Trop Sao Paulo. 2021 Jan 29;63:e11

Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this disease in the world, affecting mainly children and pregnant women in Africa. Despite the programs carried out to control this disease, drug resistance and invertebrate vector resistance to insecticides have generated difficulties. An efficient vaccine against malaria would be a strategy with a high impact on the eradication and control of this disease.

Genetic polymorphism of the N-terminal region in circumsporozoite surface protein of Plasmodium falciparum field isolates from Sudan

October 7, 2019 - 15:17 -- Open Access
Nouh S. Mohamed, Musab M. Ali Albsheer, Mohamed M. Elbasheir, et al.
Malaria Journal 2019 18:333, 1 October 2019

Malaria caused by Plasmodium falciparum parasite is still known to be one of the most significant public health problems in sub-Saharan Africa. Genetic diversity of the Sudanese P. falciparum based on the diversity in the circumsporozoite surface protein (PfCSP) has not been previously studied. Therefore, this study aimed to investigate the genetic diversity of the N-terminal region of the pfcsp gene.

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