The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10588 malaria professionals are enjoying the free benefits of MalariaWorld today

Genetic polymorphism

Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax

September 8, 2020 - 11:46 -- Open Access
Author(s): 
Tuấn Cường Võ, Hương Giang Lê, Jung-Mi Kang, Mya Moe, Haung Naw, Moe Kyaw Myint, Jinyoung Lee, Woon-Mok Sohn, Tong-Soo Kim and Byoung-Kuk Na
Reference: 
Malaria Journal 2020 19:303, 4 September 2020

Circumsporozoite surface protein (CSP) of malaria parasites has been recognized as one of the leading vaccine candidates. Clinical trials of vaccines for vivax malaria incorporating Plasmodium vivax CSP (PvCSP) have demonstrated their effectiveness in preventing malaria, at least in part. However, genetic diversity of pvcsp in the natural population remains a major concern.

Genetic polymorphism of Plasmodium falciparum circumsporozoite protein on Bioko Island, Equatorial Guinea and global comparative analysis

July 14, 2020 - 09:34 -- Open Access
Author(s): 
Hui-Ying Huang, Xue-Yan Liang, Min Lin, et al.
Reference: 
Malaria Journal 2020 19:245, 13 July 2020

Plasmodium falciparum circumsporozoite protein (PfCSP) is a potential malaria vaccine candidate, but various polymorphisms of the pfcsp gene among global P. falciparum population become the major barrier to the effectiveness of vaccines. This study aimed to investigate the genetic polymorphisms and natural selection of pfcsp in Bioko and the comparison among global P. falciparum population.

Genetic polymorphism of merozoite surface protein-3 in Myanmar Plasmodium falciparum field isolates

May 20, 2020 - 10:23 -- Open Access
Author(s): 
Hương Giang Lê, Thị Lam Thái, Byoung-Kuk Na, et al.
Reference: 
Malaria Journal 2020 19:184, 19 May 2020

Plasmodium falciparum merozoite surface protein-3 (PfMSP-3) is a target of naturally acquired immunity against P. falciparum infection and is a promising vaccine candidate because of its critical role in the erythrocyte invasion of the parasite. Understanding the genetic diversity of pfmsp-3 is important for recognizing genetic nature and evolutionary aspect of the gene in the natural P. falciparum population and for designing an effective vaccine based on the antigen.

Genetic polymorphism of histidine rich protein 2 in Plasmodium falciparum isolates from different infection sources in Yunnan Province, China

January 6, 2020 - 16:05 -- Open Access
Author(s): 
Ying Dong, Shuping Liu, Yan Deng, Yanchun Xu, Mengni Chen, Yan Liu and Jingpo Xue
Reference: 
Malaria Journal 2019 18:446, 30 December 2019

Failed diagnoses of some falciparum malaria cases by RDTs are constantly reported in recent years. Plasmodium falciparum histidine-rich protein 2 (pfhpr2) gene deficiency has been found to be the major reason of RDTs failure in many countries. This article analysed the deletion of pfhpr2 gene of falciparum malaria cases isolated in Yunnan Province, China.

Genetic polymorphism of merozoite surface proteins 1 and 2 of Plasmodium falciparum in the China-Myanmar border region

December 2, 2019 - 17:54 -- Open Access
Author(s): 
Zhang CL, Zhou HN, Liu Q, Yang YM
Reference: 
Malar J. 2019 Nov 19;18(1):367

Malaria is a major public health problem in the China-Myanmar border region. The genetic structure of malaria parasite may affect its transmission model and control strategies. The present study was to analyse genetic diversity of Plasmodium falciparum by merozoite surface proteins 1 and 2 (MSP1 and MSP2) and to determine the multiplicity of infection in clinical isolates in the China-Myanmar border region.

Country: 

Genetic polymorphism of merozoite surface proteins 1 and 2 of Plasmodium falciparum in the China–Myanmar border region

November 26, 2019 - 13:26 -- Open Access
Author(s): 
Cang-Lin Zhang, Hong-Ning Zhou, Quan Liu and Ya-Ming Yang
Reference: 
Malaria Journal 2019 18: 367, 19 November 2019

Malaria is a major public health problem in the China–Myanmar border region. The genetic structure of malaria parasite may affect its transmission model and control strategies. The present study was to analyse genetic diversity of Plasmodium falciparum by merozoite surface proteins 1 and 2 (MSP1 and MSP2) and to determine the multiplicity of infection in clinical isolates in the China–Myanmar border region.

Medical Condition: 

Genetic polymorphism of the N-terminal region in circumsporozoite surface protein of Plasmodium falciparum field isolates from Sudan

October 7, 2019 - 15:17 -- Open Access
Author(s): 
Nouh S. Mohamed, Musab M. Ali Albsheer, Mohamed M. Elbasheir, et al.
Reference: 
Malaria Journal 2019 18:333, 1 October 2019

Malaria caused by Plasmodium falciparum parasite is still known to be one of the most significant public health problems in sub-Saharan Africa. Genetic diversity of the Sudanese P. falciparum based on the diversity in the circumsporozoite surface protein (PfCSP) has not been previously studied. Therefore, this study aimed to investigate the genetic diversity of the N-terminal region of the pfcsp gene.

Country: 
Medical Condition: 
Subscribe to RSS - Genetic polymorphism