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host microRNA

Targeted repression of Plasmodium apicortin by host microRNA impairs malaria parasite growth and invasion

June 6, 2020 - 15:05 -- Open Access
Chakrabarti M, Garg S, Rajagopal A, Pati S, Singh S
Dis Model Mech. 2020 Jun 3;13(6):dmm042820

Mature human erythrocytes contain a rich pool of microRNAs (miRNAs), which result from differentiation of the erythrocytes during the course of haematopoiesis. Recent studies have described the effect of erythrocytic miRNAs on the invasion and growth of the malaria parasite Plasmodium falciparum during the asexual blood stage of its life cycle. In this work, we have identified two erythrocytic miRNAs, miR-150-3p and miR-197-5p, that show favourable in silico hybridization with Plasmodium apicortin, a protein with putative microtubule-stabilizing properties.

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