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NOT Open Access | Choline and PEG dually modified artemether nano delivery system targeting intra-erythrocytic Plasmodium and its pharmacodynamics in vivo

March 2, 2021 - 15:17 -- NOT Open Access
Wang R, Shi G, Chai L, Wang R, Zhang G, Ren G, Zhang S
Drug Dev Ind Pharm. 2021 Mar 1:1-11

The choline derivative (CD) and polyethylene-glycol (PEG) dually modified artemether (ARM) nanostructured lipid carriers (CD-PEG-ARM-NLC) have been designed to prolong the circulation of ARM in blood, as well as to develop targeting for new permeability pathways (NPPs) and erythrocyte choline carriers (ECCs) that are expressed on the Plasmodium-infected erythrocyte membrane.

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

June 3, 2020 - 15:54 -- Open Access
Subudhi AK, O'Donnell AJ, Pain A, et al.
Nat Commun. 2020 Jun 2; 11(1):2763

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown.

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