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plasmodium falciparum Rrp6

Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites

June 3, 2020 - 15:47 -- Open Access
Fan Y, Shen S, Zhang Q, et al.
mBio. 2020 Jun 2; 11(3):e01110-20

The heterochromatin environment plays a central role in silencing genes associated with the malaria parasite’s development, survival in the host, and transmission to the mosquito vector. However, the underlying mechanism regulating the dynamic chromatin structure is not understood yet. Here, we have uncovered that Plasmodium falciparum Rrp6, an orthologue of eukaryotic RNA exosome-associated RNase, controls the silencing of heterochromatic genes.

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