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clp proteolytic system

Not Open Access | Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system

June 2, 2020 - 14:02 -- NOT Open Access
Author(s): 
Florentin A, Stephens DR, Brooks CF, Baptista RP, Muralidharan V
Reference: 
Proc Natl Acad Sci U S A. 2020 Jun 1:201919501

The human malaria parasite, Plasmodium falciparum, contains an essential plastid called the apicoplast. Most apicoplast proteins are encoded by the nuclear genome and it is unclear how the plastid proteome is regulated. Here, we study an apicoplast-localized caseinolytic-protease (Clp) system and how it regulates organelle proteostasis. Using null and conditional mutants, we demonstrate that the P. falciparum Clp protease (PfClpP) has robust enzymatic activity that is essential for apicoplast biogenesis.

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