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NADP(H) oxidoreductase

Not Open Access | C-terminal aromatic residue of Plasmodium ferredoxin important for the interaction with ferredoxin:NADP(H) oxidoreductase: possible involvement for artemisinin resistance of human malaria parasites

June 1, 2020 - 16:48 -- NOT Open Access
Kimata-Ariga Y, Sakamoto A, Kamatani M, Saitoh T, Hase T
J Biochem. 2020 May 29:mvaa060

The malaria parasite (Plasmodium sp.) contains a plastid-derived organelle called the apicoplast, which is essential for the growth of the parasite. In this organelle, a redox system comprising plant-type ferredoxin (Fd) and Fd:NADP(H) oxidoreductase (FNR) supplies reducing power for the crucial metabolic pathways. Electron transfer between P. falciparum Fd (PfFd) and FNR (PfFNR) is performed with higher affinity and specificity than those of plant Fd and FNR. We investigated the structural basis for such superior protein-protein interaction by focusing on the Plasumodium-specific regions of PfFd.

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