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rapid diagnostic test

Predictors of malaria rapid diagnostic test positivity in a high burden area of Paletwa Township, Chin State in Western Myanmar

January 13, 2021 - 11:30 -- Open Access
Aung PL, Soe MT, Oo TL, Khin A, Thi A, Zhao Y, Cao Y, Cui L, Kyaw MP, Parker DM.
Infect Dis Poverty. 2021 Jan 11;10(1):6

Despite major reductions in malaria burden across Myanmar, clusters of the disease continue to persist in specific subregions. This study aimed to assess the predictors of test positivity among people living in Paletwa Township of Chin State, an area of persistently high malaria burden.

Trends of Malaria Morbidity and Mortality from 2010 to 2017 in Bale Zone, Ethiopia: Analysis of Surveillance Data

December 16, 2020 - 12:49 -- Open Access
Sani Kalil F, Hasen Bedaso M, Kabeta Wario S
Infect Drug Resist. 2020 Dec 8;13:4379-4387

Malaria is the major public health problem in sub-Saharan Africa, including Ethiopia. Ongoing malaria surveillance data analysis is useful for assessing incidences, trends over time, and evaluating the effectiveness of malaria prevention and control programs.

Impact of Plasmodium falciparum gene deletions on malaria rapid diagnostic test performance

November 4, 2020 - 15:15 -- Open Access
Michelle L. Gatton, Alisha Chaudhry, Jane Cunningham, et al.
Malaria Journal 2020 19:392, 4 November 2020

Malaria rapid diagnostic tests (RDTs) have greatly improved access to diagnosis in endemic countries. Most RDTs detect Plasmodium falciparum histidine-rich protein 2 (HRP2), but their sensitivity is seriously threatened by the emergence of pfhrp2-deleted parasites. RDTs detecting P. falciparum or pan-lactate dehydrogenase (Pf- or pan-LDH) provide alternatives. The objective of this study was to systematically assess the performance of malaria RDTs against well-characterized pfhrp2-deleted P. falciparum parasites.

Evaluation of the malaria reporting system supported by the District Health Information System 2 in Solomon Islands

October 20, 2020 - 16:26 -- Open Access
Kinley Wangdi, Haribondu Sarma, John Leaburi, Emma McBryde and Archie C. A. Clements
Malaria Journal 2020 19:372, 17 October 2020

District Health Information Systems 2 (DHIS2) is used for supporting health information management in 67 countries, including Solomon Islands. However, there have been few published evaluations of the performance of DHIS2-enhanced disease reporting systems, in particular for monitoring infectious diseases such as malaria. The aim of this study was to evaluate DHIS2 supported malaria reporting in Solomon Islands and to develop recommendations for improving the system.

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

October 13, 2020 - 12:43 -- Open Access
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich and Thierry Rolling
Malaria Journal 2020 19:366, 12 October 2020

Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present study aims to assess the prevalence of asymptomatic Plasmodium falciparum and non-falciparum infections in Ghanaian adults in the Ashanti region during the high transmission season.

Severe malaria in Cameroon: Pattern of disease in children at the Yaounde Gynaeco-Obstetric and Pediatric hospital

October 7, 2020 - 16:07 -- Open Access
Chiabi A, Djimafo ANM, Nguefack S, Mah E, Nguefack Dongmo F, Angwafo F 3rd
J Infect Public Health. 2020 Oct;13(10):1469-1472

Malaria is the most widely spread parasitic disease in the world, especially in the tropics affecting mostly children and pregnant women. In children, mostly under-fives carry the heaviest burden in terms of morbidity and mortality. The aim of this study was to determine the epidemiological and clinical aspects, and outcome of children 3 months to 15 years old with severe malaria at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH), a referral hospital in Yaounde, Cameroon.

NOT Open Access | Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion

October 7, 2020 - 14:48 -- NOT Open Access
Gibbons J, Qin J, Malla P, Wang Z, Brashear A, Wang C, Miao J, Adams JH, Kim K, Jiang R, Cui L
J Infect Dis. 2020 Oct 1;222(9):1561-1569

Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false-negative rapid diagnostic test (RDT) results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions.

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting

October 1, 2020 - 15:36 -- Open Access
Du YQ, Ling XX, Jin JJ, Zhou HY, Zhu S, Zhu GD, Wang W, Cao J, Huang JY
Infect Dis Poverty. 2020 Sep 29;9(1):135

As more and more countries approaching the goal of malaria elimination, malaria rapid diagnostic tests (RDT) was recomendated to be a diagnostic strategy to achieve and maintain the statute of malaria free, as it’s less requirments on equipment and experitise than microscopic examination. But there are very few economic evaluations to confirm whether RDT was cost-effective in the setting of malaria elimination. This research aimed to offer evidence for helping decision making on malaria diagnosis strategy.

Rapid reduction of malaria transmission following the introduction of indoor residual spraying in previously unsprayed districts: an observational analysis of Mopti Region, Mali, in 2017

September 22, 2020 - 10:18 -- Open Access
Joseph Wagman, Idrissa Cissé, Molly Robertson, et al.
Malaria Journal 2020 19:340, 19 September 2020

The National Malaria Control Programme (NMCP) of Mali has had recent success decreasing malaria transmission using 3rd generation indoor residual spraying (IRS) products in areas with pyrethroid resistance, primarily in Ségou and Koulikoro Regions. In 2015, national survey data showed that Mopti Region had the highest under 5-year-old (u5) malaria prevalence at 54%—nearly twice the national average—despite having high access to long-lasting insecticidal nets (LLINs) and seasonal malaria chemoprevention (SMC). Accordingly, in 2016 the NMCP and other stakeholders shifted IRS activities from Ségou to Mopti. Here, the results of a series of observational analyses utilizing routine malaria indicators to evaluate the impact of this switch are presented.

NOT Open Access | Comparision of the various routine diagnostic modalities of malaria and a new method: the Parasight™ platform

September 5, 2020 - 15:49 -- NOT Open Access
Das S, Rajkumari N, Revathi U, Gururajan A
J Parasit Dis. 2020 Sep;44(3):528-535

Malaria is one of most important parasitic disease, which is still much prevalent in India. The burden of malaria in India is complex and the proportions of Plasmodium vivax and Plasmodium falciparum vary across India, because of the highly variable malaria eco-epidemiological profiles, transmission factors, and the presence of multiple Plasmodium species and Anopheles vectors.


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