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rapid diagnostic test

Rapid reduction of malaria transmission following the introduction of indoor residual spraying in previously unsprayed districts: an observational analysis of Mopti Region, Mali, in 2017

September 22, 2020 - 10:18 -- Open Access
Author(s): 
Joseph Wagman, Idrissa Cissé, Molly Robertson, et al.
Reference: 
Malaria Journal 2020 19:340, 19 September 2020

The National Malaria Control Programme (NMCP) of Mali has had recent success decreasing malaria transmission using 3rd generation indoor residual spraying (IRS) products in areas with pyrethroid resistance, primarily in Ségou and Koulikoro Regions. In 2015, national survey data showed that Mopti Region had the highest under 5-year-old (u5) malaria prevalence at 54%—nearly twice the national average—despite having high access to long-lasting insecticidal nets (LLINs) and seasonal malaria chemoprevention (SMC). Accordingly, in 2016 the NMCP and other stakeholders shifted IRS activities from Ségou to Mopti. Here, the results of a series of observational analyses utilizing routine malaria indicators to evaluate the impact of this switch are presented.

NOT Open Access | Comparision of the various routine diagnostic modalities of malaria and a new method: the Parasight™ platform

September 5, 2020 - 15:49 -- NOT Open Access
Author(s): 
Das S, Rajkumari N, Revathi U, Gururajan A
Reference: 
J Parasit Dis. 2020 Sep;44(3):528-535

Malaria is one of most important parasitic disease, which is still much prevalent in India. The burden of malaria in India is complex and the proportions of Plasmodium vivax and Plasmodium falciparum vary across India, because of the highly variable malaria eco-epidemiological profiles, transmission factors, and the presence of multiple Plasmodium species and Anopheles vectors.

Genetic diversity of Plasmodium falciparum in Grande Comore Island

September 5, 2020 - 14:55 -- Open Access
Author(s): 
Nasserdine Papa Mze, Hervé Bogreau, Cyrille K. Diedhiou, Vendela Herdell, Silai Rahamatou, Amy K. Bei, Sarah K. Volkman, Leonardo Basco, Souleymane Mboup and Ambroise D. Ahouidi
Reference: 
Malaria Journal 2020 19:320, 3 September 2020

Despite several control interventions resulting in a considerable decrease in malaria prevalence in the Union of the Comoros, the disease remains a public health problem with high transmission in Grande Comore compared to neighbouring islands. In this country, only a few studies investigating the genetic diversity of Plasmodium falciparum have been performed so far. For this reason, this study aims to examine the genetic diversity of P. falciparum by studying samples collected in Grande Comore in 2012 and 2013, using merozoite surface protein 1 (msp1), merozoite surface protein 2 (msp2) and single nucleotide polymorphism (SNP) genetic markers.

Prevalence and determinants of malaria infection among children of local farmers in Central Malawi

September 1, 2020 - 09:52 -- Open Access
Author(s): 
Emmanuel Chilanga, Delphine Collin-Vézina, Heather MacIntosh, Claudia Mitchell and Katrina Cherney
Reference: 
Malaria Journal 2020 19:308, 27 August 2020

Malaria is a leading cause of morbidity and mortality among children under 5 years in Malawi, and especially among those from rural areas of central Malawi. The goal of this study was to examine the prevalence and determinants of malaria infection among children in rural areas of Dowa district in central Malawi.

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

August 24, 2020 - 13:25 -- Open Access
Author(s): 
Agius PA, Cutts JC, Fowkes FJI, et al.
Reference: 
PLoS Med. 2020 Aug 20;17(8):e1003177

The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of public health campaigns. We aimed to quantify the effectiveness of repellent distributed by the village health volunteer (VHV) network in the Greater Mekong Subregion (GMS) in reducing malaria in order to advance regional malaria elimination.

Malaria preventive practices and delivery outcomes: A cross-sectional study of parturient women in a tertiary hospital in Eastern Uganda

August 10, 2020 - 15:53 -- Open Access
Author(s): 
Nekaka R, Nteziyaremye J, Oboth P, Iramiot JS, Wandabwa J
Reference: 
PLoS ONE 15(8): e0237407

Uganda ranks third in the number of deaths attributable to malaria and has some of the highest recorded malaria transmission rates in the general population. Malaria in Pregnancy is associated with detrimental effects for the mother and unborn baby and these effects seem to have long term effects and consequences on the life of the baby. Despite the preventive measures put in place by the World Health Organization in antenatal care, the burden of malaria in pregnancy is still high. We determined the use of malaria preventive strategies during pregnancy and the presence of plasmodium infection, anemia, and low birth weight babies at delivery among parturient women at Mbale regional referral hospital in eastern Uganda.

A five-year trend analysis of malaria surveillance data in selected zones of Amhara region, Northwest Ethiopia

July 30, 2020 - 13:26 -- Open Access
Author(s): 
Lankir D, Solomon S, Gize A
Reference: 
BMC Public Health. 2020 Jul 28; 20(1):1175

Trend analysis of malaria surveillance data is essential to inform stakeholders on progress towards malaria control. From the total 387,096 cases of malaria reported in Amhara region in 2017, 167,079 (43.2%) cases were in Central, North and West Gondar zones. From this total figure of zones, 15,445 (9.2%) were ≤ 5 years which contributes 4% of cases in the region. So, the purpose of this study was to analyze trends of malaria parasite in Selected Zones of Amhara Region, Northwest Ethiopia.

Point prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana

July 28, 2020 - 14:06 -- Open Access
Author(s): 
Okyere B, Owusu-Ofori A, Dickerson T, et al.
Reference: 
PLoS ONE 15(7): e0232874

Plasmodium infection among children is a serious public health problem. Asymptomatic malaria infection among humans serves as a significant reservoir for transmitting Plasmodium to uninfected Anopheles mosquitoes, fueling malaria endemicity and asymptomatic malaria may progress to clinical malaria. Therefore, prompt and accurate diagnosis of malaria infection is crucial for the management and control of malaria, especially in endemic areas. This study assessed the point prevalence of asymptomatic malaria infection and evaluated the performance of malaria Rapid Diagnostic Tests (RDT), light microscopy and nested PCR (nPCR) for the diagnosis of asymptomatic malaria infection in a paediatric population in the Atwima Nwabiagya North district, Ghana.

Characterization of putative drug resistant biomarkers in Plasmodium falciparum isolated from Ghanaian blood donors

July 26, 2020 - 13:43 -- Open Access
Author(s): 
Aninagyei E, Duedu KO, Rufai T, Tetteh CD, Chandi MG, Ampomah P, Acheampong DO
Reference: 
BMC Infect Dis. 2020 Jul 22;20(1):533

Plasmodium falciparum parasites, which could harbour anti-malaria drug resistance genes, are commonly detected in blood donors in malaria-endemic areas. Notwithstanding, anti-malaria drug resistant biomarkers have not been characterized in blood donors with asymptomatic P. falciparum infection.

Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

July 15, 2020 - 15:17 -- Open Access
Author(s): 
Ruben O. Conner, Yakou Dieye, Caterina Guinovart, et al.
Reference: 
Malaria Journal 2020 19:252, 14 July 2020

Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and evidence from different transmission settings is needed.

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