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rapid diagnostic test

Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia

July 7, 2020 - 12:48 -- Open Access
Author(s): 
Daniels RF, Schaffner SF, Bennett A, Porter TR, Yukich JO, Mulube C, Mambwe B, Mwenda MC, Chishimba S, Bridges DJ, Moonga H, Hamainza B, Chizema Kawesha E, Miller JM, Steketee RW, Wirth DF, Eisele TP, Hartl DL, Volkman SK
Reference: 
Am. J. Trop. Med. Hyg., 00(0), 2020, pp. 1–8

A mass drug administration trial was carried out in Southern Province, Zambia, between 2014 and 2016, in conjunction with a standard of care package that included improved surveillance, increased access to malaria case management, and sustained high levels of vector control coverage. This was preceded by mass test and treatment in the same area from 2011 to 2013. Concordant decreases in malaria prevalence in Southern Province and deaths attributed to malaria in Zambia over this time suggest that these strategies successfully reduced the malaria burden.

NOT Open Access | Using the Ultrasensitive Alere Plasmodium falciparum Malaria Ag HRP-2(™) Rapid Diagnostic Test in the Field and Clinic in Northeastern Uganda

July 1, 2020 - 16:31 -- NOT Open Access
Author(s): 
Owalla TJ, Okurut E, Apungia G, Ojakol B, Lema J, Sean MC, Thomas EG
Reference: 
Am J Trop Med Hyg. 2020 Jun 29

The ultrasensitive Alere Plasmodium falciparum Malaria Ag histidine-rich protein 2 rapid diagnostic test (Alere uRDT) is a new diagnostic tool which is more expensive than other malaria rapid diagnostic tests (RDTs) routinely used in Ugandan clinics. The manufacturer recommends testing samples within 2 days and scoring results after 20 minutes, which may be impractical in high-volume resource-poor clinics.

A Japanese man with malaria tests negative for fever after spending 6 months in rural Kenya

June 29, 2020 - 16:22 -- Open Access
Author(s): 
Sugimoto T, Takahashi K, Matsui K, Asada M, Kaneko O, Ariyoshi K
Reference: 
Trop Med Health. 2020 Jun 24; 48:52

A previously healthy Japanese man in his fifties was admitted to our hospital because of a recurrent fever after returning from Kenya and Madagascar. He was ambulant with a body temperature of 36.6 °C. His physical examination revealed normal except for tender hepatomegaly.

Utility of Plasmodium falciparum DNA from rapid diagnostic test kits for molecular analysis and whole genome amplification

May 29, 2020 - 14:49 -- Open Access
Author(s): 
Suttipat Srisutham, Kanokon Suwannasin, Vivek Bhakta Mathema, Kanlaya Sriprawat, Frank M. Smithuis, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong
Reference: 
Malaria Journal 2020 19:193, 27 May 2020

Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of different methods for whole genome amplification were investigated.

Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

May 25, 2020 - 08:47 -- Open Access
Author(s): 
Valérie Briand, Gilles Cottrell, Nadine Fievet, et al.
Reference: 
Malaria Journal 2020 19:188, 24 May 2020

While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for the detection of infections of low parasite density in pregnant women.

Glutamate dehydrogenase: a novel candidate to diagnose Plasmodium falciparum through rapid diagnostic test in blood specimen from fever patients

April 15, 2020 - 14:21 -- Open Access
Author(s): 
Kori LD, Valecha N, Anvikar AR
Reference: 
Sci Rep. 2020 Apr 14;10(1):6307

In recent years, Plasmodium falciparum histidine-rich protein 2 gene deletion has been reported in India. Such isolates are prone to selective transmission and thus form a challenge to case management. As most of the rapid malaria diagnostic tests are based on the detection of HRP2 protein in the blood, we attempted to use Glutamate Dehydrogenase (GDH) as a biomarker for the diagnosis of P. falciparum.

Performance evaluation of a prototype rapid diagnostic test for combined detection of gambiense-human African trypanosomiasis and malaria

April 10, 2020 - 16:41 -- Open Access
Author(s): 
Lumbala C, Matovu E, Sendagire H, Kazibwe AJN, Likwela JL, Muhindo Mavoko H, Kayembe S, Lutumba P, Biéler S, Van Geertruyden JP, Ndung'u JM
Reference: 
PLoS Negl Trop Dis 14(4): e0008168

Malaria is endemic in all regions where gambiense or rhodesiense human African trypanosomiasis (HAT) is reported, and both diseases have similarities in their symptomatology. A combined test could be useful for both diseases and would facilitate integration of the screening for gambiense HAT (gHAT) and malaria diagnosis. This study aimed to evaluate a combined prototype rapid diagnostic test (RDT) for gHAT and malaria.

Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in 2 Transmission Settings: Haiti 2017

February 22, 2020 - 17:08 -- Open Access
Author(s): 
Rogier E, Hamre KES, Joseph V, Plucinski MM, Presume J, Romilus I, Mondelus G, Elisme T, van den Hoogen L, Lemoine JF, Drakeley C, Ashton RA, Chang MA, Existe A, Boncy J, Stresman G, Druetz T, Eisele TP
Reference: 
The Journal of Infectious Diseases, Volume 221, Issue 5, 1 March 2020, Pages 786–795

Accurate malaria diagnosis is foundational for control and elimination, and Haiti relies on histidine-rich protein 2 (HRP2)–based rapid diagnostic tests (RDTs) identifying Plasmodium falciparum in clinical and community settings. In 2017, 1 household and 2 easy-access group surveys tested all participants (N = 32 506) by conventional and high-sensitivity RDTs. A subset of blood samples (n = 1154) was laboratory tested for HRP2 by bead-based immunoassay and for P. falciparum 18S rDNA by photo-induced electron transfer polymerase chain reaction.

Use of a highly-sensitive rapid diagnostic test to screen for malaria in pregnancy in Indonesia

January 20, 2020 - 15:58 -- Open Access
Author(s): 
Vera T. Unwin, Rukhsana Ahmed, Emily R. Adams, et al.
Reference: 
Malaria Journal 2020 19:28, 16 January 2020

The sensitivity of rapid diagnostic tests (RDTs) for malaria is inadequate for detecting low-density, often asymptomatic infections, such as those that can occur when screening pregnant women for malaria. The performance of the Alere™ Ultra-sensitive Malaria Ag Plasmodium falciparum RDT (uRDT) was assessed retrospectively in pregnant women in Indonesia.

Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

December 23, 2019 - 14:37 -- Open Access
Author(s): 
Ley B, Winasti Satyagraha A, Price RN, et al.
Reference: 
PLoS Med. 2019 Dec 13; 16(12):e1002992.

To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. This systematic review and individual patient meta-analysis assessed the utility of a qualitative lateral flow assay from Access Bio/CareStart (Somerset, NJ) (CareStart Screening test for G6PD deficiency) for the diagnosis of G6PDd compared to the gold standard spectrophotometry (International Prospective Register of Systematic Reviews [PROSPERO]: CRD42019110994).

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