The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11147 malaria professionals are enjoying the free benefits of MalariaWorld today

GTPase

Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A

June 1, 2020 - 16:01 -- Open Access
Author(s): 
Patil H, Hughes KR, Lemgruber L, Philip N, Dickens N, Starnes GL, Waters AP
Reference: 
PLoS Pathog 16(5): e1008091

Plasmodium species are apicomplexan parasites whose zoites are polarized cells with a marked apical organisation where the organelles associated with host cell invasion and colonization reside. Plasmodium gametes mate in the mosquito midgut to form the spherical and presumed apolar zygote that morphs during the following 24 hours into a polarized, elongated and motile zoite form, the ookinete. Endocytosis-mediated protein transport is generally necessary for the establishment and maintenance of polarity in epithelial cells and neurons, and the small GTPase RAB11A is an important regulator of protein transport via recycling endosomes.

Subscribe to RSS - GTPase