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endemic area

NOT Open Access | Delayed clinical presentation of Plasmodium falciparum malaria after leaving an endemic area: a tale of two patients

September 30, 2020 - 11:55 -- NOT Open Access
Pennington K, Ives ST, Frosch AEP, Shaughnessy MK
J Travel Med. 2020 Sep 26;27(6):taaa092

Malaria remains a leading cause of global morbidity and mortality. The incubation period for Plasmodium falciparum malaria is typically <1 month, and most patients develop symptoms within 2 months of exposure.

Evaluation of the colorimetric malachite green loop-mediated isothermal amplification (MG-LAMP) assay for the detection of malaria species at two different health facilities in a malaria endemic area of western Kenya

September 10, 2020 - 08:55 -- Open Access
James Gachugia, Winnie Chebore, Kephas Otieno, Caroline Wangari Ngugi, Adano Godana and Simon Kariuki
Malaria Journal 2020 19:329, 9 September 2020

Prompt diagnosis and effective malaria treatment is a key strategy in malaria control. However, the recommended diagnostic methods, microscopy and rapid diagnostic tests (RDTs), are not supported by robust quality assurance systems in endemic areas. This study compared the performance of routine RDTs and smear microscopy with a simple molecular-based colorimetric loop-mediated isothermal amplification (LAMP) at two different levels of the health care system in a malaria-endemic area of western Kenya.

Investigation of glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence in a Plasmodium vivax-endemic area in the Republic of Korea (ROK)

September 2, 2020 - 11:47 -- Open Access
Wonsig Lee, Sang-Eun Lee, Min Jun Lee and Kyung Tae Noh
Malaria Journal 2020 19:317, 1 September 2020

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most prevalent inborn disorder. This X-chromosome-linked recessive disease affects more than 400 million people globally, and is associated with haemolytic anaemia after medication with the anti-latent malaria drug, primaquine. To prevent malaria, the Republic of Korea (ROK) Army administers malaria chemoprophylaxis. Due to the previously low G6PD deficiency prevalence in the ROK, prior to primaquine administration, testing for G6PD deficiency was not mandatory. In this study, to evaluate the risk from malaria chemoprophylaxis in the ROK, G6PD deficiency prevalence was investigated.

NOT Open Access | Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil

May 27, 2020 - 10:41 -- NOT Open Access
Costa EMF, Amador ECC, Silva ES, Alvarenga CO, Pereira PE, Póvoa MM, Cunha MG
Acta Trop. 2020 May 23:105537

Plasmodium vivax remains an important cause of malaria in South America and Asia, and analyses of the antibody immune response are being used to identify biomarker of parasite exposure. The IgG antibody naturally acquired predominantly occurs against targets on blood-stage parasites, including C-terminal of the merozoite surface protein 1 (MSP1-19). Epidemiological and immunological evidence has been showed that antibodies to malaria parasite antigens are lost in the absence of ongoing exposure.

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