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ER tubule-forming proteins

NOT Open Access | A Plasmodium homolog of ER tubule-forming proteins is required for parasite virulence

May 21, 2020 - 06:48 -- NOT Open Access
Shi X, Hai L, Govindasamy K, Gao J, Coppens I, Hu J, Wang Q, Bhanot P
Mol Microbiol. 2020 May 20

Reticulon and REEP family of proteins stabilize the high curvature of endoplasmic reticulum (ER) tubules. P. berghei  Yop1 (Pb Yop1) is a REEP5 homolog in Plasmodium . Here we characterize its function using a gene‐knockout (Pb yop1∆). Pb yop1∆ asexual stage parasites display abnormal ER architecture and an enlarged digestive vacuole. The erythrocytic cycle of Pb yop1∆ parasites is severely attenuated and the incidence of experimental cerebral malaria is significantly decreased in Pb yop1∆‐infected mice.

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