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Bukina Faso

Risk of malaria in young children after periconceptional iron supplementation

November 28, 2020 - 15:56 -- Open Access
Gies S, Roberts SA, Diallo S, Lompo OM, Tinto H, Brabin BJ
Matern Child Nutr. 2020 Nov 25:e13106

This study in Burkina Faso investigated whether offspring of young mothers who had received weekly periconceptional iron supplementation in a randomised controlled trial were at increased risk of malaria. A child safety survey was undertaken in the peak month of malaria transmission towards the end of the trial to assess child iron biomarkers, nutritional status, anaemia and malaria outcomes. Antenatal iron biomarkers, preterm birth, fetal growth restriction and placental pathology for malaria and chorioamnionitis were assessed.

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods

October 21, 2020 - 08:14 -- Open Access
Epopa PS, Millogo AA, Collins CM, North AR, Benedict MQ, Tripet F, OʼLoughlin S, Dabiré RK, Ouédraogo GA, Diabaté A
Parasit Vectors. 2020 Oct 15;13(1):516

One of the promising current approaches to curb malaria lies in genetic vector control, the implementation of which will require an improved understanding of the movement of genetic constructs among mosquito populations. To predict potential gene flow from one area to another, it is important to begin to understand mosquito dynamics outside of the commonly-sampled village areas, and thus how genes may move between villages. This study assessed the presence and relative abundance of mosquitoes in a 6-km corridor between two villages in western Burkina Faso.

A cohort study to identify risk factors for Plasmodium falciparum infection in Burkinabe children: implications for other high burden high impact countries

October 20, 2020 - 16:24 -- Open Access
Jean Baptiste Yaro, Alphonse Ouedraogo, Anne L. Wilson, et al.
Malaria Journal 2020 19:371, 16 October 2020

Progress in controlling malaria has stalled in recent years. Today the malaria burden is increasingly concentrated in a few countries, including Burkina Faso, where malaria is not declining. A cohort study was conducted to identify risk factors for malaria infection in children in southwest Burkina Faso, an area with high insecticide-treated net (ITN) coverage and insecticide-resistant vectors.

Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria

October 13, 2020 - 12:48 -- Open Access
Dieng MM, Diawara A, Idaghdour Y, et al.
Nat Commun. 2020 Oct 9;11(1):5093

The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria.

Iron Status of Burkinabé Adolescent Girls Predicts Malaria Risk in the Following Rainy Season

May 21, 2020 - 06:33 -- Open Access
Brabin L, Roberts SA, Tinto H, Gies S, Diallo S, Brabin B
Nutrients. 2020 May 16; 12(5):E1446

High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial.

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