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malaria protection

Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection

May 21, 2020 - 06:21 -- Open Access
Obeng-Adjei N, Larremore DB, Tran TM, et al.
JCI Insight. 2020 May 19:137262

Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum infected erythrocytes to the microvasculature mediated via specific interactions between PfEMP1 variant domains to host endothelial receptors. Naturally acquired antibodies against specific PfEMP1 variants can play an important role in clinical protection against malaria.

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