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chemokines gene polymorphisms

Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India

September 30, 2019 - 13:35 -- Open Access
Prabhanjan P. Gai, Welmoed van Loon, Frank P. Mockenhaupt, et al.
Malaria Journal 2019 18:328, 24 September 2019

Duffy blood group antigens serve as receptors for Plasmodium vivax invasion into erythrocytes, and they are determined by polymorphisms of the Duffy antigen receptor for chemokines (DARC), also known as Fy glycoprotein (FY). Duffy negativity, i.e., absence of the antigens, protects against P. vivax infection and is rare among non-African populations. However, data on DARC polymorphisms and their impact on Plasmodium infection in India are scarce.

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