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iron deficiency

NOT Open Access | Malaria is a cause of iron deficiency in African children

February 25, 2021 - 08:29 -- NOT Open Access
Muriuki JM, Mentzer AJ, Atkinson SH, et al.
Nat Med. 2021 Feb 22

Malaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID1. To test the hypothesis that malaria might cause ID, we used sickle cell trait (HbAS, rs334 ), a genetic variant that confers specific protection against malaria2, as an instrumental variable in Mendelian randomization analyses.

Relationship between blood Lead status and anemia in Ugandan children with malaria infection

November 18, 2020 - 11:03 -- Open Access
Mukisa A, Kasozi D, Aguttu C, Vuzi PC, Kyambadde J
BMC Pediatr. 2020 Nov 14;20(1):521

In Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities including helminths and Lead toxicity. Environmental Lead levels accounts for one’s blood Lead (BL) levels. Blood Lead competitively blocks iron absorption, inhibits hemoglobin (Hb) biosynthesis and elevates free erythrocyte protoporphyrin (FEP) levels. Lead toxicity’s contribution towards anemia pathogenesis, especially during malaria infection has not been studied. Concomitant exposure to both malaria infection and Lead pollution, exacerbates the anemia status. This study therefore aimed at expounding the anemia status of these Ugandan children aged under 5years who are exposed to both malaria infection and environmental Lead pollution.

Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children

June 12, 2020 - 13:58 -- Open Access
Abuga KM, Rockett KA, Muriuki JM, Koch O, Nairz M, Sirugo G, Bejon P, Kwiatkowski DP, Prentice AM, Atkinson SH
Wellcome Open Res. 2020 Jun 2; 5:40

Anaemia is a major public health concern especially in African children living in malaria-endemic regions. Interferon-gamma (IFN-γ) is elevated during malaria infection and is thought to influence erythropoiesis and iron status. Genetic variants in the IFN-γ gene (IFNG) are associated with increased IFN-γ production. We investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes of IFNG in relation to nutritional iron status and anaemia in Gambian children over a malaria season.

Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children

June 9, 2020 - 11:33 -- Open Access
Bundi CK, Nalwoga A, Atkinson SH, et al.
Clin Infect Dis. 2020 Jun 7:ciaa728

Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody responses to Plasmodium falciparum malaria.

NOT Open Access | Delayed iron does not alter cognition or behavior among children with severe malaria and iron deficiency

May 14, 2020 - 12:28 -- NOT Open Access
Ssemata AS, Hickson M, Ssenkusu JM, Cusick SE, Nakasujja N, Opoka RO, Kroupina M, Georgieff MK, Bangirana P, John CC
Pediatr Res. 2020 May 13

Malaria and iron deficiency (ID) in childhood are both associated with cognitive and behavioral dysfunction. The current standard of care for children with malaria and ID is concurrent antimalarial and iron therapy. Delaying iron therapy until inflammation subsides could increase iron absorption but also impair cognition.

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