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public health

NOT Open Access | Climate based malaria forecasting system for Andhra Pradesh, India

September 5, 2020 - 15:51 -- NOT Open Access
Author(s): 
Mopuri R, Kakarla SG, Mutheneni SR, Kadiri MR, Kumaraswamy S
Reference: 
J Parasit Dis. 2020 Sep;44(3):497-510

Malaria is a major public health problem in tropical and subtropical countries of the World. During the year 1999, Visakhapatnam district of Andhra Pradesh, India experienced a major epidemic of malaria, and nearly 41,805 cases were reported. Hence, a retrospective malaria surveillance study was conducted from 2001 to 2016 and reported nearly a total of 149,317 malaria cases during the study period.

The biology of unconventional invasion of Duffy-negative reticulocytes by Plasmodium vivax and its implication in malaria epidemiology and public health

August 24, 2020 - 14:13 -- Open Access
Author(s): 
Lemu Golassa, Lucas Amenga-Etego, Eugenia Lo and Alfred Amambua-Ngwa
Reference: 
Malaria Journal 2020 19:299, 24 August 2020

Plasmodium vivax has been largely neglected over the past century, despite a widespread recognition of its burden across region where it is endemic. The parasite invades reticulocytes, employing the interaction between Plasmodium vivax Duffy binding protein (PvDBP) and human Duffy antigen receptor for chemokines (DARC). However, P. vivax has now been observed in Duffy-negative individuals, presenting a potentially serious public health problem as the majority of African populations are Duffy-negative.

The potential public health consequences of COVID-19 on malaria in Africa

August 10, 2020 - 16:04 -- Open Access
Author(s): 
Sherrard-Smith E, Hogan AB, Churcher TS, et al.
Reference: 
Nat Med. 2020 Aug 7

The burden of malaria is heavily concentrated in sub-Saharan Africa (SSA) where cases and deaths associated with COVID-19 are rising1. In response, countries are implementing societal measures aimed at curtailing transmission of SARS-CoV-22,3. Despite these measures, the COVID-19 epidemic could still result in millions of deaths as local health facilities become overwhelmed4.

Leveraging big data for public health: Mapping malaria vector suitability in Malawi with Google Earth Engine

August 5, 2020 - 16:15 -- Open Access
Author(s): 
Frake AN, Peter BG, Walker ED, Messina JP
Reference: 
PLoS ONE 15(8): e0235697

In an era of big data, the availability of satellite-derived global climate, terrain, and land cover imagery presents an opportunity for modeling the suitability of malaria disease vectors at fine spatial resolutions, across temporal scales, and over vast geographic extents. Leveraging cloud-based geospatial analytical tools, we present an environmental suitability model that considers water resources, flow accumulation areas, precipitation, temperature, vegetation, and land cover. In contrast to predictive models generated using spatially and temporally discontinuous mosquito presence information, this model provides continuous fine-spatial resolution information on the biophysical drivers of suitability.

Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017–2019)

May 25, 2020 - 08:56 -- Open Access
Author(s): 
Romaric Nzoumbou-Boko, Chris-Boris Gildas Panté-Wockama, Didier Ménard, et al.
Reference: 
Malaria Journal 2020 19:191, 24 May 2020

Over the last decade, artemisinin-based combination therapy (ACT) has contributed substantially to the decrease in malaria-related morbidity and mortality. The emergence of Plasmodium falciparum parasites resistant to artemisinin derivatives in Southeast Asia and the risk of their spread or of local emergence in sub-Saharan Africa are a major threat to public health. This study thus set out to estimate the proportion of P. falciparum isolates, with Pfkelch13 gene mutations associated with artemisinin resistance previously detected in Southeast Asia.

Assessment of malaria as a public health problem in and around Arjo Didhessa sugar cane plantation area, Western Ethiopia

May 14, 2020 - 12:19 -- Open Access
Author(s): 
Dufera M, Dabsu R, Tiruneh G
Reference: 
BMC Public Health. 2020 May 12;20(1):655

Although much progress has been made in reducing malaria morbidity and mortality worldwide in the last decade, nationally malaria remains the third leading cause of death and still considered a major public health problem. Therefore, this study was aimed to assess malaria as a public health problem in and around the sugar cane plantation area of Arjo Didhessa sugar factory, Western Ethiopia.

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