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viral diseases

Chloroquine against malaria, cancers and viral diseases

September 23, 2020 - 08:44 -- Open Access
Author(s): 
Zhou W, Wang H, Yang Y, Chen ZS, Zou C, Zhang J
Reference: 
Drug Discov Today. 2020 Sep 16:S1359-6446(20)30367-6

Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites.

NOT Open Access | Impact of venereal transmission on the dynamics of vertically transmitted viral diseases among mosquitoes

May 13, 2020 - 13:59 -- NOT Open Access
Author(s): 
Nadim SS, Ghosh I, Martcheva M, Chattopadhyay J
Reference: 
Math Biosci. 2020 May 5:108366

Despite centuries of enormous control efforts, mosquito-borne diseases continue to show upward trend of morbidity. According to WHO reports, malaria caused 438000 deaths in the year 2015 and dengue cases has been increased 30-fold over the last five decades. To control these diseases, it is necessary to understand the transmission dynamics of them among mosquitoes. There are some vertically transmitted mosquito-borne diseases which can also be spread among mosquitoes through sexual contact (e.g., dengue, zika, chikungunya).

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