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hmgb2 attenuated

A genetically hmgb2 attenuated blood stage P. berghei induces crossed-long live protection

May 12, 2020 - 16:47 -- Open Access
Briquet S, Lawson-Hogban N, Peronet R, Mécheri S, Vaquero C
PLoS ONE 15(5): e0232183

Due to the lack of efficiency to control malaria elicited by sub-unit vaccine preparations, vaccination with live-attenuated Plasmodium parasite as reported 70 years ago with irradiated sporozoites regained recently a significant interest. The complex life cycle of the parasite and the different stages of development between mammal host and anopheles do not help to propose an easy vaccine strategy.

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