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pharmacokinetic properties

NOT Open Access | Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

October 28, 2020 - 09:51 -- NOT Open Access
Horatscheck A, Andrijevic A, Chibale K, et al.
J Med Chem. 2020 Oct 25

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity.

Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children

May 7, 2020 - 13:24 -- Open Access
Ding J, Coldiron ME, Assao B, Guindo O, Blessborn D, Winterberg M, Grais RF, Koscalova A, Langendorf C, Tarning J
Clin Pharmacol Ther. 2020 May;107(5):1179-1188

Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC. Here, we evaluated the population pharmacokinetic properties of amodiaquine and its active metabolite, desethylamodiaquine, in children receiving SMC under directly observed ideal conditions (n = 136), and the adherence of SMC at an implementation phase in children participating in a case‐control study to evaluate SMC effectiveness (n = 869).

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