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Plug for the parasitophorous duct: a solution of two conundra

October 20, 2020 - 16:21 -- Open Access
Prapon Wilairat and Saranya Auparakkitanon
Malaria Journal 2020 19:370, 16 October 2020

We present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate membrane lysis to allow merozoite egress.

NOT Open Access | EXP1 is required for organisation of EXP2 in the intraerythrocytic malaria parasite vacuole

May 7, 2020 - 13:20 -- NOT Open Access
Nessel T, Beck JM, Rayatpisheh S, Jami-Alahmadi Y, Wohlschlegel JA, Goldberg DE, Beck JR
Cell Microbiol. 2020 May;22(5):e13168

Intraerythrocytic malaria parasites reside within a parasitophorous vacuole membrane (PVM) that closely overlays the parasite plasma membrane. Although the PVM is the site of several transport activities essential to parasite survival, the basis for organisation of this membrane system is unknown. Here, we performed proximity labeling at the PVM with BioID2, which highlighted a group of single‐pass integral membrane proteins that constitute a major component of the PVM proteome but whose function remains unclear.

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