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CYP3A4

Older adults, Zinc deficiency, Artemisia and Corona

August 19, 2020 - 19:57 -- Pierre Lutgen

submitted by Pierre Lutgen, Jerome Munyangi and Mutaz Akkawi

Zinc (Zn) plays an essential role in many biological processes including immune response. Impaired Zn status promotes immune dysfunction, and it has been associated with enhanced chronic inflammation during aging. Zinc has a pivotal role in the entire immune system fostering resistance to infections by virus, fungi and bacteria. The immune system is strongly impaired by zinc deficiency, predominantly the cell-mediated response by T-lymphocytes.

Not Open Access | Influence of CYP2C8, CYP3A4 and CYP3A5 host genotypes on early recurrence of Plasmodium vivax

May 6, 2020 - 15:59 -- NOT Open Access
Author(s): 
Almeida ACG, Puça MCB, Melo GC, et al.
Reference: 
Antimicrob Agents Chemother. 2020 May 4. pii: AAC.02125-19

CYP450 enzymes are involved in biotransformation of chloroquine (CQ), but the role of the different metabolism profiles of this drug has not been properly investigated in relation to P. vivax recurrences. To investigate the influence of CYPs genotypes associated with CQ-metabolism on early recurrence rates of P. vivax, a case-control study was carried out. Cases included patients presenting an early recurrence (CQ-recurrent), defined as recurrence during the first 28 days after initial infection, plasma concentrations of CQ plus desethylchloroquine (DCQ, the major CQ metabolite) higher than 100 ng/mL.

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